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• W2022059703 abstract "Cerebrospinal fluid (CSF) was obtained from 17 patients during acute alcohol withdrawal. Eight of these 17 patients had a second lumbar puncture a mean of 11.9 ± 8.1 (sd) days later, when the clinical signs of alcohol withdrawal had subsided. CSF 3-methoxy-4-hydroxyphen-ylglycol concentrations declined significantly (p < 0.05) during the course of alcohol withdrawal from 52.0 ± 22.1 (sd) to 39.6 ± 12.6 pM/ml. In early withdrawal, there was a significant positive correlation between CSF norepinephrine (NE) and corticotropin releasing hormone (CRH) concentrations (r= 0.95, p <0.001). Both NE and CRH concentrations correlated positively with diastolic blood pressure (r= 0.88, p < 0.001 and r= 0.62, p < 0.05, respectively). In all samples, CSF 5-hydroxyindole acetic acid concentrations correlated positively with CSF-homovanillic acid concentrations (r= 0.83, p < 0.001). These findings indicate significant perturbations of the noradrenergic neuronal system and a change in CRH-NE interactions during acute alcohol withdrawal." @default.
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• W2022059703 date "1994-12-01" @default.
• W2022059703 modified "2023-09-27" @default.
• W2022059703 title "Neurochemical Correlates of Sympathetic Activation during Severe Alcohol Withdrawal" @default.
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• W2022059703 doi "https://doi.org/10.1111/j.1530-0277.1994.tb01429.x" @default.
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