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- W2022059775 abstract "U conditions, a wide range of biological processes exhibit a diurnal rhythm of approximately 24 h (the term circadian arises from the Latin, circaΩapproximately, diemΩday). The most obvious rhythm is the one related to variations in the sleep/wake cycle, but almost all aspects of the internal environment undergo such changes over a 24-h period. This oscillation occurs in parallel to the daily alteration in external conditions that our rotatory planet imposes on all species. Thus, a teleological perspective of circadian function would posit that such internal organization allows adequate adaptation to the changing external environment. However, there is ample evidence to indicate that circadian rhythms arise from an internal time-keeping system that functions even in the absence of external cues (1). The existence of a ‘‘biological clock’’ with its afferent/efferent connections allows the organism to foresee and anticipate the modifications in the external environment that occur during the day/night cycle. Abnormal rhythms of several biological parameters have been described in patients with cirrhosis. The robustness of these findings will be influenced by the frequency of recording, and few studies have utilized continuous or very frequent samples in patients with liver disease. Furthermore, a diurnal variation cannot be truly termed circadian until it is shown that the rhythm persists under conditions of a constant external environment. Still, most biological oscillations are shown to persist under controlled circumstances, and diurnal variations under natural conditions can be viewed as reflecting circadian processes. Reports of abnormal rhythmicity in liver disease include such diverse processes as the lack of diurnal variation of arterial pressure in continuous 24-h recordings (2), the blunted rhythm of several hormones, such as angiotensin and aldosterone (3), the nocturnal rise in portal pressure (4) and alterations of the rhythm of plasma melatonin" @default.
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- W2022059775 title "Abnormalities of circadian rhythmicity in liver disease" @default.
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- W2022059775 doi "https://doi.org/10.1016/s0168-8278(98)80268-7" @default.
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