FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022061294> ?p ?o ?g. }

• W2022061294 endingPage "321" @default.
• W2022061294 startingPage "308" @default.
• W2022061294 abstract "Schwann cells (SchC), the myelinating glia of the peripheral nervous system, are immunocompetent cells and secrete a variety of immune and inflammatory mediators. In this report, we show that rat SchC in vitro express both C3 mRNA and protein in response to dibutyryl cyclic AMP (dbcAMP) and the cytokines IFN-γ, TNF-α, and IL-1β. SchC in culture constitutively expressed low levels of C3 which were significantly upregulated upon stimulation with 1mM dbcAMP by 24 hours, and persisted up to 120 hours. This response was minimally enhanced by costimulation with 100 U/ml IFN-γ, whereas costimulation with 100 U/ml IFN-γ together with 150–450 ng/ml TNF-α induced a greatly increased C3 response. TNF-α alone did not induce C3 expression in SchC. Cycloheximide inhibited this dbcAMP-dependent delayed C3 production, thus implying an intermediary signal in the induction pathway requiring protein synthesis. Treatment with 0.1–10 ng/ml IL-1β for 0–72 hours induced C3 mRNA and protein in a dose-dependent manner. C3 mRNA was detectable at 1 hour and mRNA and protein peaked by 6–12 hours on stimulation with 10 ng/ml IL-1β, or at 48 hours with 1.0 ng/ml IL-1β. Furthermore, IL-1β mRNA was detected at 6 hours in dbcAMP-treated SchC, preceding the dbcAMP-induced C3 expression by 18 hours. Induction of C3 mRNA and protein by dbcAMP at 24 hours was inhibited >85% by a neutralizing anti-IL-1β antibody and 76% with an IL-1 receptor antagonist. This suggests that dbcAMP-induced synthesis of IL-1β mediates the C3 production by SchC in an autocrine/paracrine fashion by binding to a functional IL-1 receptor expressed on the surface of SchC. Endoneurial IL-1 and C3 production by SchC may therefore contribute to the inflammatory events associated with peripheral nerve demyelination. GLIA 20:308–321, 1997. © 1997 Wiley-Liss, Inc." @default.
• W2022061294 created "2016-06-24" @default.
• W2022061294 creator A5026322312 @default.
• W2022061294 creator A5030136101 @default.
• W2022061294 creator A5049843826 @default.
• W2022061294 date "1997-08-01" @default.
• W2022061294 modified "2023-09-26" @default.
• W2022061294 title "Dibutyryl cyclic AMP and inflammatory cytokines mediate C3 expression in schwann cells" @default.
• W2022061294 cites W1503620318 @default.
• W2022061294 cites W1513178777 @default.
• W2022061294 cites W1525664688 @default.
• W2022061294 cites W1526247294 @default.
• W2022061294 cites W1533456562 @default.
• W2022061294 cites W1560013316 @default.
• W2022061294 cites W1600496839 @default.
• W2022061294 cites W1608665304 @default.
• W2022061294 cites W1810651552 @default.
• W2022061294 cites W1866736421 @default.
• W2022061294 cites W1899513052 @default.
• W2022061294 cites W1920787626 @default.
• W2022061294 cites W1942672363 @default.
• W2022061294 cites W1947896897 @default.
• W2022061294 cites W1980469685 @default.
• W2022061294 cites W1981089875 @default.
• W2022061294 cites W1981849628 @default.
• W2022061294 cites W1983473899 @default.
• W2022061294 cites W1983599511 @default.
• W2022061294 cites W1991970463 @default.
• W2022061294 cites W1998225973 @default.
• W2022061294 cites W2004496200 @default.
• W2022061294 cites W2004813091 @default.
• W2022061294 cites W2005697934 @default.
• W2022061294 cites W2006718965 @default.
• W2022061294 cites W2007776511 @default.
• W2022061294 cites W2012555291 @default.
• W2022061294 cites W2016069416 @default.
• W2022061294 cites W2017455885 @default.
• W2022061294 cites W2023479137 @default.
• W2022061294 cites W2024139637 @default.
• W2022061294 cites W2026107691 @default.
• W2022061294 cites W2026394731 @default.
• W2022061294 cites W2027196477 @default.
• W2022061294 cites W2037889018 @default.
• W2022061294 cites W2038360740 @default.
• W2022061294 cites W2042295629 @default.
• W2022061294 cites W2046434701 @default.
• W2022061294 cites W2053212420 @default.
• W2022061294 cites W2058465293 @default.
• W2022061294 cites W2064394426 @default.
• W2022061294 cites W2065965177 @default.
• W2022061294 cites W2079867354 @default.
• W2022061294 cites W2082205690 @default.
• W2022061294 cites W2084141686 @default.
• W2022061294 cites W2085374906 @default.
• W2022061294 cites W2086368742 @default.
• W2022061294 cites W2087138604 @default.
• W2022061294 cites W2088615921 @default.
• W2022061294 cites W2088848783 @default.
• W2022061294 cites W2091455355 @default.
• W2022061294 cites W2091695331 @default.
• W2022061294 cites W2103417481 @default.
• W2022061294 cites W2109220113 @default.
• W2022061294 cites W2114569219 @default.
• W2022061294 cites W2117797189 @default.
• W2022061294 cites W2122305954 @default.
• W2022061294 cites W2126961438 @default.
• W2022061294 cites W2127977922 @default.
• W2022061294 cites W2146538952 @default.
• W2022061294 cites W2158115811 @default.
• W2022061294 cites W4255912943 @default.
• W2022061294 cites W7411795 @default.
• W2022061294 doi "https://doi.org/10.1002/(sici)1098-1136(199708)20:4<308::aid-glia4>3.0.co;2-1" @default.
• W2022061294 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9262235" @default.
• W2022061294 hasPublicationYear "1997" @default.
• W2022061294 type Work @default.
• W2022061294 sameAs 2022061294 @default.
• W2022061294 citedByCount "20" @default.
• W2022061294 countsByYear W20220612942014 @default.
• W2022061294 countsByYear W20220612942016 @default.
• W2022061294 countsByYear W20220612942021 @default.
• W2022061294 countsByYear W20220612942023 @default.
• W2022061294 crossrefType "journal-article" @default.
• W2022061294 hasAuthorship W2022061294A5026322312 @default.
• W2022061294 hasAuthorship W2022061294A5030136101 @default.
• W2022061294 hasAuthorship W2022061294A5049843826 @default.
• W2022061294 hasConcept C104317684 @default.
• W2022061294 hasConcept C105580179 @default.
• W2022061294 hasConcept C126322002 @default.
• W2022061294 hasConcept C127561419 @default.
• W2022061294 hasConcept C134018914 @default.
• W2022061294 hasConcept C153911025 @default.
• W2022061294 hasConcept C170493617 @default.
• W2022061294 hasConcept C17991360 @default.
• W2022061294 hasConcept C202751555 @default.
• W2022061294 hasConcept C203014093 @default.
• W2022061294 hasConcept C24998067 @default.
• W2022061294 hasConcept C2778128677 @default.
• W2022061294 hasConcept C2778690821 @default.

• next