Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022062879> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2022062879 abstract "The aim of this study was to develop a method to predict a tracer's α-value in the human brain on the basis of animal data. The α-value is the ratio of the conversion rate and the back-diffusion rate (k3/k2) and is one of the critical kinetic features of the detection sensitivity of target molecule activity, such as enzyme activity, in the measurement of PET and single-photon emission computed tomography using an irreversible-type radiotracer.The α-value in the rat brain was estimated by a simultaneous assay of the tracer uptake and the target biochemical activity using N-[C]-methylpiperidin-4-yl acetate ([C]MP4A) and N-[C]-methylpiperidin-4-yl propionate ([C]MP4P) as test tracers, both of which are metabolic trapping tracers for measurement of brain acetylcholinesterase. The α-value in humans was then extrapolated from the α-value in rats by considering the differences between the species. The predicted human α-values were compared with those obtained from the kinetic analyses of human PET studies using [C]MP4A and [C]MP4P.The α-values in the human brain cortex were predicted to be 0.51±0.1 for MP4A and 0.25±0.05 for MP4P. These results were close to values reported in other PET studies: 0.48±0.1 to 0.73±0.2 for MP4A and 0.15±0.04 to 0.18±0.04 for MP4P.The α-value predicted by this method would be used for practical selection or development of irreversible-type radiotracers for human use." @default.
- W2022062879 created "2016-06-24" @default.
- W2022062879 creator A5004891665 @default.
- W2022062879 creator A5023878612 @default.
- W2022062879 creator A5030087345 @default.
- W2022062879 creator A5072866366 @default.
- W2022062879 creator A5074481547 @default.
- W2022062879 creator A5076355935 @default.
- W2022062879 date "2012-10-01" @default.
- W2022062879 modified "2023-09-27" @default.
- W2022062879 title "A method to predict the ratio of the tracer conversion rate to the tracer back-diffusion rate of an irreversible-type radiotracer in humans by preclinical evaluations" @default.
- W2022062879 cites W1965036463 @default.
- W2022062879 cites W1965500524 @default.
- W2022062879 cites W1966161855 @default.
- W2022062879 cites W1970340214 @default.
- W2022062879 cites W1971048984 @default.
- W2022062879 cites W1995595980 @default.
- W2022062879 cites W2007856779 @default.
- W2022062879 cites W2019776303 @default.
- W2022062879 cites W2020279062 @default.
- W2022062879 cites W2025664264 @default.
- W2022062879 cites W2041631206 @default.
- W2022062879 cites W2042023686 @default.
- W2022062879 cites W2058747520 @default.
- W2022062879 cites W2065154151 @default.
- W2022062879 cites W2074682417 @default.
- W2022062879 cites W2078754525 @default.
- W2022062879 cites W2082429131 @default.
- W2022062879 cites W2138885654 @default.
- W2022062879 cites W2281158719 @default.
- W2022062879 doi "https://doi.org/10.1097/mnm.0b013e328356fbc3" @default.
- W2022062879 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22850605" @default.
- W2022062879 hasPublicationYear "2012" @default.
- W2022062879 type Work @default.
- W2022062879 sameAs 2022062879 @default.
- W2022062879 citedByCount "0" @default.
- W2022062879 crossrefType "journal-article" @default.
- W2022062879 hasAuthorship W2022062879A5004891665 @default.
- W2022062879 hasAuthorship W2022062879A5023878612 @default.
- W2022062879 hasAuthorship W2022062879A5030087345 @default.
- W2022062879 hasAuthorship W2022062879A5072866366 @default.
- W2022062879 hasAuthorship W2022062879A5074481547 @default.
- W2022062879 hasAuthorship W2022062879A5076355935 @default.
- W2022062879 hasConcept C121332964 @default.
- W2022062879 hasConcept C185544564 @default.
- W2022062879 hasConcept C185592680 @default.
- W2022062879 hasConcept C2775842073 @default.
- W2022062879 hasConcept C2778863792 @default.
- W2022062879 hasConcept C2780014933 @default.
- W2022062879 hasConcept C2989005 @default.
- W2022062879 hasConcept C55493867 @default.
- W2022062879 hasConcept C69357855 @default.
- W2022062879 hasConcept C71924100 @default.
- W2022062879 hasConcept C97355855 @default.
- W2022062879 hasConceptScore W2022062879C121332964 @default.
- W2022062879 hasConceptScore W2022062879C185544564 @default.
- W2022062879 hasConceptScore W2022062879C185592680 @default.
- W2022062879 hasConceptScore W2022062879C2775842073 @default.
- W2022062879 hasConceptScore W2022062879C2778863792 @default.
- W2022062879 hasConceptScore W2022062879C2780014933 @default.
- W2022062879 hasConceptScore W2022062879C2989005 @default.
- W2022062879 hasConceptScore W2022062879C55493867 @default.
- W2022062879 hasConceptScore W2022062879C69357855 @default.
- W2022062879 hasConceptScore W2022062879C71924100 @default.
- W2022062879 hasConceptScore W2022062879C97355855 @default.
- W2022062879 hasLocation W20220628791 @default.
- W2022062879 hasLocation W20220628792 @default.
- W2022062879 hasOpenAccess W2022062879 @default.
- W2022062879 hasPrimaryLocation W20220628791 @default.
- W2022062879 hasRelatedWork W2001277786 @default.
- W2022062879 hasRelatedWork W2022062879 @default.
- W2022062879 hasRelatedWork W2041110074 @default.
- W2022062879 hasRelatedWork W2062941811 @default.
- W2022062879 hasRelatedWork W2094283771 @default.
- W2022062879 hasRelatedWork W23424515 @default.
- W2022062879 hasRelatedWork W2735048813 @default.
- W2022062879 hasRelatedWork W2953077429 @default.
- W2022062879 hasRelatedWork W3011383635 @default.
- W2022062879 hasRelatedWork W797255455 @default.
- W2022062879 isParatext "false" @default.
- W2022062879 isRetracted "false" @default.
- W2022062879 magId "2022062879" @default.
- W2022062879 workType "article" @default.