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• W2022063004 abstract "Abstract: Vasomotor effects of various agonists were tested on isolated human epicardial coronary arteries and veins at resting tension and after precontraction with U46619. Acetylcholine relaxed all arteries with intact endothelium but only some endothelium-denuded arteries. Most veins did not relax to acetylcholine. Higher concentrations of acetylcholine induced powerful contractions of all arteries and veins. Preincubation with atropine significantly lowered the pD2 values but not Emax values for contractile responses to acetylcholine in arteries and veins (pA2 value for atropine 9.1 arteries and 9.6 veins). Vasoactive intestinal peptide, human α-calcitonin gene-related peptide and substance P potently relaxed all arteries with intact endothelium and all veins. Removal of the arterial endothelium abolished relaxation to substance P in most arteries whereas responses to vasoactive intestinal peptide were unaffected, and for a-calcitonin gene-related peptide the pD2 value but not the Emax value was significantly lowered. In both arteries and veins, the antagonists α-calcitonin gene-related peptide (8-37) and spantide lowered significantly the potency for a-calcitonin gene-related peptide and substance P, respectively, without significant changes in Emax values (pA2 value for α-calcitonin gene-related peptide (8-37) 7.9 arteries and 7.9 veins, for spantide 7.6 arteries and 8.1 veins)." @default.
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• W2022063004 date "1996-04-01" @default.
• W2022063004 modified "2023-09-26" @default.
• W2022063004 title "Effect of Parasympathetic and Sensory Transmitters on Human Epicardial Coronary Arteries and Veins" @default.
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• W2022063004 doi "https://doi.org/10.1111/j.1600-0773.1996.tb00217.x" @default.
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