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- W2022065219 abstract "The adhesion molecule lymphocyte function-associated antigen (LFA)-1 plays a key role in immune surveillance and response. Its conformation is spatially and temporally regulated, enabling adhesion and deadhesion during T-cell migration. LFA-1 adhesion to its major ligand intercellular adhesion molecule 1 is controlled by adaptor proteins which bind the cytoplasmic tail of the β (2) subunit. Cathepsin X, a cysteine carboxypeptidase, promotes T-cell migration and morphological changes by cleaving the β (2) cytoplasmic tail of LFA-1. In this way, it modulates the affinity of LFA-1 for structural adaptors talin-1 and α-actinin-1 and enables the stepwise transition between intermediate and high-affinity conformations of LFA-1, an event that is necessary for effective T-cell function. Cathepsin X regulation that would allow precise modulation of LFA-1 affinity has a great potential for anti-LFA-1 therapy." @default.
- W2022065219 created "2016-06-24" @default.
- W2022065219 creator A5059675124 @default.
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- W2022065219 date "2011-01-01" @default.
- W2022065219 modified "2023-09-26" @default.
- W2022065219 title "LFA-1 fine-tuning by cathepsin X" @default.
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- W2022065219 doi "https://doi.org/10.1002/iub.505" @default.
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