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• W2022068304 abstract "Conclusion: Renal failure, treatment of bifurcation lesions, in-stent restenosis, and cessation of clopidogrel therapy correlate with thrombosis of coronary artery stents. Summary: Stent thrombosis is an infrequent, but serious complication of drug-eluting coronary artery stents. The authors sought to establish risk factors for coronary artery stent thrombosis associated with drug-eluting stents. A total of 2974 consecutive patients were treated with drug-eluting coronary artery stents, and 38 (1.27%) were identified by angiography to have evidence of stent thrombosis. Thrombosis of the stent occurred acutely in five patients, ≤30 days in 25 patients, and >30 days in eight patients. The authors compared procedural angiographic and clinical factors of the patients with stent thrombosis vs 2936 consecutive patients who were treated with drug-eluting stents for coronary disease and who did not experience stent thrombosis during a period of 12 months of follow-up. Patients with stent thrombosis compared with patients without stent thrombosis had a higher frequency of diabetes, postprocedural renal failure, and chronic renal failure. Patients with stent thrombosis had more bifurcation lesions and a trend toward smaller diameter stents. The incidence of discontinuation of clopidogrel therapy was higher in patients with stent thrombosis (36.8%) vs patients without stent thrombosis (10.7%, P < .0001). At 6 months, mortality was significantly higher in patients with stent thrombosis compared with those without stent thrombosis (31% vs 3%; P < 0.001). Multivariant analysis suggested renal failure, bifurcation lesions, in-stent restenosis, and cessation of clopidogrel therapy correlated with stent thrombosis (P < .05). Comment: Stent thrombosis may relate to impaired or delayed re-endothelialization secondary to the drug-eluting properties of the stent. Regardless of cause, sudden thrombosis of coronary artery stents is now recognized as having a high mortality rate, likely because of abrupt occlusion of an otherwise widely patent coronary artery. Of the potential variables influencing stent thrombosis, it appears that cessation of clopidogrel therapy is the risk factor that both the patient and physician can modify. More work will be needed to determine whether lifelong clopidogrel therapy is required in patients with drug-eluting coronary artery stents." @default.
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• W2022068304 date "2006-10-01" @default.
• W2022068304 modified "2023-10-17" @default.
• W2022068304 title "Correlates and long-term outcomes of angiographically proven stent thrombosis with sirolimus-paclitaxel-eluting stents" @default.
• W2022068304 doi "https://doi.org/10.1016/j.jvs.2006.08.056" @default.
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