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- W2022069375 abstract "Distribution of [14C]MCA and its derivatives in mouse tissues The distribution of radioactivity due to 3-methylcholanthrene (MCA) and/or its metabolites was evaluated in different organs of mothers, foetuses and newborns at 6 and 60–66 h following a single intragastric administration of 1 mg of [14C]MCA to pregnant CF-1 mice. The extent of bound [14C]MCA nd/or its metabolites to nuclear and cytoplasmic proteins was evaluated in organs which were proven to be either susceptible (lung) or non-susceptible (kidney) to the carcinogenic effect of MCA. The present data indicate a slightly higher level of free and bound MCA in the subcellular fractions of the lung than in the kidney and concurrently a higher level of covalently bound MCA to the nuclear DNA in the lungs than in the kidney." @default.
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- W2022069375 date "1973-08-01" @default.
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- W2022069375 title "Distribution tissulaire, infracellulaire et fixation du [14C]MCA ou de ses derives sur les constituants cellulaires ches les souris meres, les foetus et les neonates" @default.
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- W2022069375 doi "https://doi.org/10.1016/0009-2797(73)90017-3" @default.
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