FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022070133> ?p ?o ?g. }

• W2022070133 endingPage "1022" @default.
• W2022070133 startingPage "1011" @default.
• W2022070133 abstract "Mesotheliomas with pleomorphic features are rare and only a few studies on this mesothelioma variant have been published. Little information regarding the immunoprofile of these tumors and none on their electron microscopic features was included in these studies. Herein are reported 10 cases of pleomorphic mesothelioma that were investigated using a large panel of immunohistochemical markers, 4 of which were also studied by electron microscopy. All of the patients were men and seven had a history of asbestos exposure. Nine of the cases originated in the pleura and one in the peritoneum. Histologically, the tumors were characterized by being composed of large, often discohesive, cells that varied in size and shape, had dense abundant eosinophilic cytoplasm, and single or multiple irregular nuclei, which often contained one or several large nucleoli. Mitotic activity was high and atypical mitoses frequent. Immunoreactivity for pan-keratin and keratin 7 was strong in all of the cases. Expression for calretinin, WT1, podoplanin, mesothelin and keratin 5/6 was also frequent, but variable. All cases were negative for MOC-31, carcinoembryonic antigen, CD15, TAG-72 and thyroid transcription factor-1. Electron microscopy often showed the presence of abundant long, slender microvilli on the cell membrane of the neoplastic cells. These findings demonstrate that, contrary to what has been suggested by some investigators, both immunohistochemistry and electron microscopy can be very helpful in assisting in the diagnosis of pleomorphic mesotheliomas. That the seven patients who underwent extrapleural pneumonectomy had extensive lymph node metastasis and that the median survival of those patients for whom follow-up information was available was only 8.2 months indicates that mesotheliomas with pleomorphic features are associated with highly aggressive clinical behavior. Therefore, when this subtype of epithelioid mesothelioma is present, it should be reported as it can significantly affect the prognosis and treatment of the patient." @default.
• W2022070133 created "2016-06-24" @default.
• W2022070133 creator A5078188105 @default.
• W2022070133 date "2012-07-01" @default.
• W2022070133 modified "2023-10-18" @default.
• W2022070133 title "Pleomorphic mesothelioma: report of 10 cases" @default.
• W2022070133 cites W1964275689 @default.
• W2022070133 cites W1967561798 @default.
• W2022070133 cites W1967897610 @default.
• W2022070133 cites W1978267065 @default.
• W2022070133 cites W1987045640 @default.
• W2022070133 cites W2005408275 @default.
• W2022070133 cites W2007483903 @default.
• W2022070133 cites W2018591217 @default.
• W2022070133 cites W2022220805 @default.
• W2022070133 cites W2035021811 @default.
• W2022070133 cites W2037176142 @default.
• W2022070133 cites W2037267921 @default.
• W2022070133 cites W2045444663 @default.
• W2022070133 cites W2059442449 @default.
• W2022070133 cites W2061242666 @default.
• W2022070133 cites W2065329835 @default.
• W2022070133 cites W2074125591 @default.
• W2022070133 cites W2081788327 @default.
• W2022070133 cites W2091762501 @default.
• W2022070133 cites W2110934295 @default.
• W2022070133 cites W2111158788 @default.
• W2022070133 cites W2161255631 @default.
• W2022070133 cites W4366064491 @default.
• W2022070133 cites W2138900570 @default.
• W2022070133 doi "https://doi.org/10.1038/modpathol.2012.39" @default.
• W2022070133 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22388762" @default.
• W2022070133 hasPublicationYear "2012" @default.
• W2022070133 type Work @default.
• W2022070133 sameAs 2022070133 @default.
• W2022070133 citedByCount "50" @default.
• W2022070133 countsByYear W20220701332012 @default.
• W2022070133 countsByYear W20220701332013 @default.
• W2022070133 countsByYear W20220701332014 @default.
• W2022070133 countsByYear W20220701332015 @default.
• W2022070133 countsByYear W20220701332016 @default.
• W2022070133 countsByYear W20220701332017 @default.
• W2022070133 countsByYear W20220701332018 @default.
• W2022070133 countsByYear W20220701332019 @default.
• W2022070133 countsByYear W20220701332020 @default.
• W2022070133 countsByYear W20220701332021 @default.
• W2022070133 countsByYear W20220701332022 @default.
• W2022070133 countsByYear W20220701332023 @default.
• W2022070133 crossrefType "journal-article" @default.
• W2022070133 hasAuthorship W2022070133A5078188105 @default.
• W2022070133 hasBestOaLocation W20220701331 @default.
• W2022070133 hasConcept C10205521 @default.
• W2022070133 hasConcept C121608353 @default.
• W2022070133 hasConcept C142669718 @default.
• W2022070133 hasConcept C142724271 @default.
• W2022070133 hasConcept C1491633281 @default.
• W2022070133 hasConcept C191548132 @default.
• W2022070133 hasConcept C204232928 @default.
• W2022070133 hasConcept C2776804306 @default.
• W2022070133 hasConcept C2777387746 @default.
• W2022070133 hasConcept C2777407522 @default.
• W2022070133 hasConcept C2779012181 @default.
• W2022070133 hasConcept C2779758542 @default.
• W2022070133 hasConcept C2781404787 @default.
• W2022070133 hasConcept C28328180 @default.
• W2022070133 hasConcept C54355233 @default.
• W2022070133 hasConcept C71924100 @default.
• W2022070133 hasConcept C78383274 @default.
• W2022070133 hasConcept C81241287 @default.
• W2022070133 hasConcept C86803240 @default.
• W2022070133 hasConceptScore W2022070133C10205521 @default.
• W2022070133 hasConceptScore W2022070133C121608353 @default.
• W2022070133 hasConceptScore W2022070133C142669718 @default.
• W2022070133 hasConceptScore W2022070133C142724271 @default.
• W2022070133 hasConceptScore W2022070133C1491633281 @default.
• W2022070133 hasConceptScore W2022070133C191548132 @default.
• W2022070133 hasConceptScore W2022070133C204232928 @default.
• W2022070133 hasConceptScore W2022070133C2776804306 @default.
• W2022070133 hasConceptScore W2022070133C2777387746 @default.
• W2022070133 hasConceptScore W2022070133C2777407522 @default.
• W2022070133 hasConceptScore W2022070133C2779012181 @default.
• W2022070133 hasConceptScore W2022070133C2779758542 @default.
• W2022070133 hasConceptScore W2022070133C2781404787 @default.
• W2022070133 hasConceptScore W2022070133C28328180 @default.
• W2022070133 hasConceptScore W2022070133C54355233 @default.
• W2022070133 hasConceptScore W2022070133C71924100 @default.
• W2022070133 hasConceptScore W2022070133C78383274 @default.
• W2022070133 hasConceptScore W2022070133C81241287 @default.
• W2022070133 hasConceptScore W2022070133C86803240 @default.
• W2022070133 hasIssue "7" @default.
• W2022070133 hasLocation W20220701331 @default.
• W2022070133 hasLocation W20220701332 @default.
• W2022070133 hasOpenAccess W2022070133 @default.
• W2022070133 hasPrimaryLocation W20220701331 @default.
• W2022070133 hasRelatedWork W1972700250 @default.
• W2022070133 hasRelatedWork W1991953574 @default.
• W2022070133 hasRelatedWork W2017518846 @default.
• W2022070133 hasRelatedWork W2022070133 @default.

• next