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- W2022070959 abstract "To modify the chemical structure of andrographolide by introducing hydrophilic groups, evaluate cytotoxic activity and study the structure-activity relationship of the derivatives. Key intermediate 2 was synthesized via Michael addition and reduction, followed by reacting with isocyanates to get 3a–3n. The compounds were evaluated for cytotoxic activity and NA (neuraminidase of H1N1) inhibition. Two derivatives (3f and 3m, both containing a single substituted aromatic ring) showed moderate cytotoxic activity while none of the compounds inhibited NA in the preliminary screening. Introducing aromatic ring at C-12 is advisable but the substituent can not be too large. Hydrophilic groups introduced to C-12 did not help to enhance the cyctotoxic activity, further study is in process." @default.
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- W2022070959 date "2011-01-01" @default.
- W2022070959 modified "2023-09-26" @default.
- W2022070959 title "Synthesis and Cytotoxic Activity of 12-Methyleneurea-14-deoxyandrographolide Derivatives" @default.
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- W2022070959 doi "https://doi.org/10.1016/s1875-5364(11)60019-8" @default.
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