FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022071177> ?p ?o ?g. }

• W2022071177 endingPage "1601" @default.
• W2022071177 startingPage "1595" @default.
• W2022071177 abstract "An on-line frontal analysis HPLC system was developed for the determination of the unbound concentrations of semotiadil, a new calcium antagonist with non-dihydropyridine structure, and its antipode (levosemotiadil), and was applied to the enantioselective investigation of their plasma protein binding properties. This system consists of a high-performance frontal analysis (HPFA) column, an extraction column, and an analytical column, which are connected via two switching valves. After the direct injection of the sample solution into the HPFA column, the drug was eluted as a zonal peak with a plateau region. The unbound drug concentration was determined as the drug concentration in the plateau. As low as 1.04 nM of the unbound drug was determined with good reproducibility. Semotiadil (R-isomer) and levosemotiadil (S-isomer) are bound strongly and enantioselectively to human serum albumin (HSA) and human α1-acid glycoprotein (AGP), and the enantioselectivity was reversed between these plasma proteins. While HSA binds S-isomer more strongly than the antipode, human AGP binds R-isomer more strongly. In human plasma, the unbound drug fraction was less than 1%, and the enantioselectivity was similar to that observed in AGP solution." @default.
• W2022071177 created "2016-06-24" @default.
• W2022071177 creator A5021174360 @default.
• W2022071177 creator A5024214650 @default.
• W2022071177 creator A5030003929 @default.
• W2022071177 creator A5047459475 @default.
• W2022071177 date "1997-06-01" @default.
• W2022071177 modified "2023-10-10" @default.
• W2022071177 title "Enantioselective protein binding of semotiadil and levosemotiadil determined by high-performance frontal analysis" @default.
• W2022071177 cites W1976472512 @default.
• W2022071177 cites W1992353595 @default.
• W2022071177 cites W1994585875 @default.
• W2022071177 cites W1996262571 @default.
• W2022071177 cites W1999783492 @default.
• W2022071177 cites W2007058747 @default.
• W2022071177 cites W2009500203 @default.
• W2022071177 cites W2016156706 @default.
• W2022071177 cites W2026021275 @default.
• W2022071177 cites W2030633650 @default.
• W2022071177 cites W2031241394 @default.
• W2022071177 cites W2043644354 @default.
• W2022071177 cites W2045364236 @default.
• W2022071177 cites W2048002464 @default.
• W2022071177 cites W2050823348 @default.
• W2022071177 cites W2052842209 @default.
• W2022071177 cites W2052921031 @default.
• W2022071177 cites W2054489646 @default.
• W2022071177 cites W2054792617 @default.
• W2022071177 cites W2057616517 @default.
• W2022071177 cites W2059338890 @default.
• W2022071177 cites W2061595273 @default.
• W2022071177 cites W2063090222 @default.
• W2022071177 cites W2068782647 @default.
• W2022071177 cites W2076816281 @default.
• W2022071177 cites W2077389097 @default.
• W2022071177 cites W2084603593 @default.
• W2022071177 cites W2330045211 @default.
• W2022071177 cites W3098660376 @default.
• W2022071177 cites W4300636202 @default.
• W2022071177 doi "https://doi.org/10.1016/s0731-7085(96)02053-5" @default.
• W2022071177 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9226594" @default.
• W2022071177 hasPublicationYear "1997" @default.
• W2022071177 type Work @default.
• W2022071177 sameAs 2022071177 @default.
• W2022071177 citedByCount "19" @default.
• W2022071177 countsByYear W20220711772015 @default.
• W2022071177 countsByYear W20220711772017 @default.
• W2022071177 crossrefType "journal-article" @default.
• W2022071177 hasAuthorship W2022071177A5021174360 @default.
• W2022071177 hasAuthorship W2022071177A5024214650 @default.
• W2022071177 hasAuthorship W2022071177A5030003929 @default.
• W2022071177 hasAuthorship W2022071177A5047459475 @default.
• W2022071177 hasConcept C108625454 @default.
• W2022071177 hasConcept C146543888 @default.
• W2022071177 hasConcept C165616093 @default.
• W2022071177 hasConcept C179998833 @default.
• W2022071177 hasConcept C185592680 @default.
• W2022071177 hasConcept C2776125364 @default.
• W2022071177 hasConcept C2778597219 @default.
• W2022071177 hasConcept C3020134792 @default.
• W2022071177 hasConcept C30787643 @default.
• W2022071177 hasConcept C43617362 @default.
• W2022071177 hasConcept C51639874 @default.
• W2022071177 hasConcept C51724486 @default.
• W2022071177 hasConcept C55493867 @default.
• W2022071177 hasConcept C73826308 @default.
• W2022071177 hasConceptScore W2022071177C108625454 @default.
• W2022071177 hasConceptScore W2022071177C146543888 @default.
• W2022071177 hasConceptScore W2022071177C165616093 @default.
• W2022071177 hasConceptScore W2022071177C179998833 @default.
• W2022071177 hasConceptScore W2022071177C185592680 @default.
• W2022071177 hasConceptScore W2022071177C2776125364 @default.
• W2022071177 hasConceptScore W2022071177C2778597219 @default.
• W2022071177 hasConceptScore W2022071177C3020134792 @default.
• W2022071177 hasConceptScore W2022071177C30787643 @default.
• W2022071177 hasConceptScore W2022071177C43617362 @default.
• W2022071177 hasConceptScore W2022071177C51639874 @default.
• W2022071177 hasConceptScore W2022071177C51724486 @default.
• W2022071177 hasConceptScore W2022071177C55493867 @default.
• W2022071177 hasConceptScore W2022071177C73826308 @default.
• W2022071177 hasIssue "9-10" @default.
• W2022071177 hasLocation W20220711771 @default.
• W2022071177 hasLocation W20220711772 @default.
• W2022071177 hasOpenAccess W2022071177 @default.
• W2022071177 hasPrimaryLocation W20220711771 @default.
• W2022071177 hasRelatedWork W1833459588 @default.
• W2022071177 hasRelatedWork W1859165359 @default.
• W2022071177 hasRelatedWork W1928409419 @default.
• W2022071177 hasRelatedWork W2001879558 @default.
• W2022071177 hasRelatedWork W2040383936 @default.
• W2022071177 hasRelatedWork W2068212194 @default.
• W2022071177 hasRelatedWork W2131462419 @default.
• W2022071177 hasRelatedWork W2175322173 @default.
• W2022071177 hasRelatedWork W2315413295 @default.
• W2022071177 hasRelatedWork W4232387876 @default.
• W2022071177 hasVolume "15" @default.
• W2022071177 isParatext "false" @default.
• W2022071177 isRetracted "false" @default.

• next