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• W2022072305 abstract "Electrophysiological records of unit activity were used to compare the effects of excitotoxic pallidal lesions and 6-hydroxydopamine-induced damage to the midbrain dopaminergic neurons on the discharge rates and patterns of the subthalamic neurons. Removal of the pallidal input induced a slight, but statistically significant, increase (19.5%) in the discharge rate and no change in the firing pattern when compared to control animals. The rats with a dopaminergic lesion showed greater increase (105.7%) while the firing pattern activity of the subthalamic neurons became more irregular, with burst. These results indicate that the increased activity of the subthalamic neurons following a midbrain dopaminergic lesion cannot be due solely to inhibition-disinhibition involving the striato-pallido-subthalamic pathway and induced by the striatal dopaminergic depletion." @default.
• W2022072305 created "2016-06-24" @default.
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• W2022072305 creator A5061147374 @default.
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• W2022072305 date "1996-05-01" @default.
• W2022072305 modified "2023-10-18" @default.
• W2022072305 title "Increased subthalamic neuronal activity after nigral dopaminergic lesion independent of disinhibition via the globus pallidus" @default.
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• W2022072305 doi "https://doi.org/10.1016/0306-4522(95)00535-8" @default.
• W2022072305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8730710" @default.
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