Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022075274> ?p ?o ?g. }
- W2022075274 endingPage "318" @default.
- W2022075274 startingPage "310" @default.
- W2022075274 abstract "Energy landscape of a peptide, extracted from a distal beta-hairpin of src SH3 domain, in explicit water was obtained with the multicanonical molecular dynamics. A variety of beta-hairpins with various strand-strand hydrogen bonds were found in the energy landscape at 300 K. There was no energy barrier between random-coil and hairpins. Thus, the peptide conformation can easily change from the random-coil to the hairpins in the thermal fluctuations at 300 K. The landscape also included two clusters of alpha-helices, among which an energy barrier existed, and besides, these helix clusters were separated from the other conformations. Thus, the free-energy barrier exists among the helices and the other conformations. Intermediate clusters were found between the helix and the hairpin clusters. The current study showed that the isolated state of this peptide in water fluctuates among random-coil, beta-hairpin, and alpha-helix. In SH3 domain, which has a topology of mainly beta-protein, the whole-protein folding may proceed when the segment is folded in the beta-hairpin and the other parts of the protein are coupled with the beta-hairpin in an energetically or kinetically favorite way." @default.
- W2022075274 created "2016-06-24" @default.
- W2022075274 creator A5023828983 @default.
- W2022075274 creator A5035143113 @default.
- W2022075274 creator A5038763185 @default.
- W2022075274 creator A5056979882 @default.
- W2022075274 date "2003-01-13" @default.
- W2022075274 modified "2023-10-09" @default.
- W2022075274 title "β‐Hairpins, α‐helices, and the intermediates among the secondary structures in the energy landscape of a peptide from a distal β‐hairpin of SH3 domain" @default.
- W2022075274 cites W1579792554 @default.
- W2022075274 cites W1593625064 @default.
- W2022075274 cites W1593987163 @default.
- W2022075274 cites W1964725350 @default.
- W2022075274 cites W1965800930 @default.
- W2022075274 cites W1966743338 @default.
- W2022075274 cites W1969111088 @default.
- W2022075274 cites W1976499671 @default.
- W2022075274 cites W1976597588 @default.
- W2022075274 cites W1976750427 @default.
- W2022075274 cites W1977369732 @default.
- W2022075274 cites W1977396740 @default.
- W2022075274 cites W1981536278 @default.
- W2022075274 cites W1983874169 @default.
- W2022075274 cites W1984916779 @default.
- W2022075274 cites W1985732252 @default.
- W2022075274 cites W1986775492 @default.
- W2022075274 cites W1990372288 @default.
- W2022075274 cites W1991591212 @default.
- W2022075274 cites W1993340416 @default.
- W2022075274 cites W1993534980 @default.
- W2022075274 cites W1994240328 @default.
- W2022075274 cites W2002672474 @default.
- W2022075274 cites W2003196055 @default.
- W2022075274 cites W2004757093 @default.
- W2022075274 cites W2004888349 @default.
- W2022075274 cites W2005965079 @default.
- W2022075274 cites W2020327873 @default.
- W2022075274 cites W2026101733 @default.
- W2022075274 cites W2027166643 @default.
- W2022075274 cites W2028672605 @default.
- W2022075274 cites W2028841335 @default.
- W2022075274 cites W2030522763 @default.
- W2022075274 cites W2033513390 @default.
- W2022075274 cites W2033568678 @default.
- W2022075274 cites W2040809566 @default.
- W2022075274 cites W2041595540 @default.
- W2022075274 cites W2047580257 @default.
- W2022075274 cites W2049342999 @default.
- W2022075274 cites W2049882394 @default.
- W2022075274 cites W2051302860 @default.
- W2022075274 cites W2051714667 @default.
- W2022075274 cites W2054111071 @default.
- W2022075274 cites W2055530511 @default.
- W2022075274 cites W2056446854 @default.
- W2022075274 cites W2059214571 @default.
- W2022075274 cites W2060915934 @default.
- W2022075274 cites W2062692230 @default.
- W2022075274 cites W2069877285 @default.
- W2022075274 cites W2073662901 @default.
- W2022075274 cites W2078233455 @default.
- W2022075274 cites W2081299079 @default.
- W2022075274 cites W2082251852 @default.
- W2022075274 cites W2082849614 @default.
- W2022075274 cites W2085053794 @default.
- W2022075274 cites W2086741044 @default.
- W2022075274 cites W2088809689 @default.
- W2022075274 cites W2088981849 @default.
- W2022075274 cites W2089435371 @default.
- W2022075274 cites W2095071091 @default.
- W2022075274 cites W2095340064 @default.
- W2022075274 cites W2106140689 @default.
- W2022075274 cites W2112032866 @default.
- W2022075274 cites W2114846189 @default.
- W2022075274 cites W2117285383 @default.
- W2022075274 cites W2131982602 @default.
- W2022075274 cites W2132589721 @default.
- W2022075274 cites W2135965992 @default.
- W2022075274 cites W2145010489 @default.
- W2022075274 cites W2145907202 @default.
- W2022075274 cites W2146895524 @default.
- W2022075274 cites W2153992575 @default.
- W2022075274 cites W2155946997 @default.
- W2022075274 cites W2156884294 @default.
- W2022075274 cites W2158476854 @default.
- W2022075274 cites W2159541123 @default.
- W2022075274 cites W2160451368 @default.
- W2022075274 cites W2162817985 @default.
- W2022075274 cites W2165890129 @default.
- W2022075274 cites W3101006260 @default.
- W2022075274 cites W3106241934 @default.
- W2022075274 doi "https://doi.org/10.1002/jcc.10160" @default.
- W2022075274 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12548722" @default.
- W2022075274 hasPublicationYear "2003" @default.
- W2022075274 type Work @default.
- W2022075274 sameAs 2022075274 @default.
- W2022075274 citedByCount "27" @default.
- W2022075274 countsByYear W20220752742012 @default.
- W2022075274 countsByYear W20220752742013 @default.