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- W2022075548 abstract "Studies in Caenorhabditis elegans demonstrate that disruption of the daf-2 signaling pathways extends lifespan. Similarities among the daf-2 pathway, insulin-like signaling in flies and yeast, and the mammalian insulin-like growth factor 1 (IGF-1) signaling cascade raise the possibility that modifications to IGF-1 signaling could also extend lifespan in mammals. In fact, growth hormone (GH)/IGF-1-deficient dwarf mice do live significantly longer than their wild-type counterparts. However, multiple endocrine deficiencies and developmental anomalies inherent in these models confound this interpretation. Here, we critique the current mammalian models of GH/IGF-1 deficiency and discuss the actions of GH/IGF-1 on biological aging and lifespan." @default.
- W2022075548 created "2016-06-24" @default.
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- W2022075548 date "2002-06-01" @default.
- W2022075548 modified "2023-10-14" @default.
- W2022075548 title "A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan" @default.
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- W2022075548 doi "https://doi.org/10.1016/s0168-9525(02)02696-3" @default.
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