Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022076253> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2022076253 endingPage "S213" @default.
- W2022076253 startingPage "S211" @default.
- W2022076253 abstract "Summary: Endothelin-1 (ET-1) and endothelin-3 (ET-3) induced a biphasic response (relaxation and contraction) in the guinea pig ileum. Short-term activation of protein kinase C (PKC) with phorbol 12,13-dibutyrate (PDBu) inhibited the contractile but not the relaxing component of the responses, as did H-7. Long-term pretreatment with PDBu reversed the short-term inhibition but did not affect the tachyphylaxis induced by ET-1. These results suggest that PKC contributes to ET-1 contraction but not to tachyphylaxis. The ETA antagonist BQ-123, at 34 nM, competitively inhibited ET-1 contraction, but at 340 nM the inhibition was noncompetitive. Dose-response curves for ET-1 relaxation were shifted to the left. For ET-3, BQ-123 (340 nM) only decreased the maximal contractile response of the dose-response curve without affecting the relaxation. We suggest that in this tissue there is one receptor for ET-1-induced contraction, which is competitively antagonized by BQ-123, and another one for ET-3-induced contraction, which is noncompetitively antagonized by BQ-123." @default.
- W2022076253 created "2016-06-24" @default.
- W2022076253 creator A5022571998 @default.
- W2022076253 creator A5039704730 @default.
- W2022076253 creator A5054220331 @default.
- W2022076253 creator A5073590635 @default.
- W2022076253 date "1993-01-01" @default.
- W2022076253 modified "2023-09-23" @default.
- W2022076253 title "Two Receptor Subtypes Are Involved in the Contractile Component of the Guinea Pig Ileum Responses to Endothelins" @default.
- W2022076253 doi "https://doi.org/10.1097/00005344-199322008-00057" @default.
- W2022076253 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7509947" @default.
- W2022076253 hasPublicationYear "1993" @default.
- W2022076253 type Work @default.
- W2022076253 sameAs 2022076253 @default.
- W2022076253 citedByCount "6" @default.
- W2022076253 crossrefType "journal-article" @default.
- W2022076253 hasAuthorship W2022076253A5022571998 @default.
- W2022076253 hasAuthorship W2022076253A5039704730 @default.
- W2022076253 hasAuthorship W2022076253A5054220331 @default.
- W2022076253 hasAuthorship W2022076253A5073590635 @default.
- W2022076253 hasBestOaLocation W20220762531 @default.
- W2022076253 hasConcept C11960822 @default.
- W2022076253 hasConcept C126322002 @default.
- W2022076253 hasConcept C134018914 @default.
- W2022076253 hasConcept C144980905 @default.
- W2022076253 hasConcept C149601957 @default.
- W2022076253 hasConcept C163415756 @default.
- W2022076253 hasConcept C168481208 @default.
- W2022076253 hasConcept C170493617 @default.
- W2022076253 hasConcept C185592680 @default.
- W2022076253 hasConcept C195794163 @default.
- W2022076253 hasConcept C2776885963 @default.
- W2022076253 hasConcept C2777226302 @default.
- W2022076253 hasConcept C2778815084 @default.
- W2022076253 hasConcept C2780043322 @default.
- W2022076253 hasConcept C2909649922 @default.
- W2022076253 hasConcept C55493867 @default.
- W2022076253 hasConcept C71924100 @default.
- W2022076253 hasConcept C86803240 @default.
- W2022076253 hasConceptScore W2022076253C11960822 @default.
- W2022076253 hasConceptScore W2022076253C126322002 @default.
- W2022076253 hasConceptScore W2022076253C134018914 @default.
- W2022076253 hasConceptScore W2022076253C144980905 @default.
- W2022076253 hasConceptScore W2022076253C149601957 @default.
- W2022076253 hasConceptScore W2022076253C163415756 @default.
- W2022076253 hasConceptScore W2022076253C168481208 @default.
- W2022076253 hasConceptScore W2022076253C170493617 @default.
- W2022076253 hasConceptScore W2022076253C185592680 @default.
- W2022076253 hasConceptScore W2022076253C195794163 @default.
- W2022076253 hasConceptScore W2022076253C2776885963 @default.
- W2022076253 hasConceptScore W2022076253C2777226302 @default.
- W2022076253 hasConceptScore W2022076253C2778815084 @default.
- W2022076253 hasConceptScore W2022076253C2780043322 @default.
- W2022076253 hasConceptScore W2022076253C2909649922 @default.
- W2022076253 hasConceptScore W2022076253C55493867 @default.
- W2022076253 hasConceptScore W2022076253C71924100 @default.
- W2022076253 hasConceptScore W2022076253C86803240 @default.
- W2022076253 hasIssue "Supplement 8" @default.
- W2022076253 hasLocation W20220762531 @default.
- W2022076253 hasLocation W20220762532 @default.
- W2022076253 hasLocation W20220762533 @default.
- W2022076253 hasOpenAccess W2022076253 @default.
- W2022076253 hasPrimaryLocation W20220762531 @default.
- W2022076253 hasRelatedWork W1983371938 @default.
- W2022076253 hasRelatedWork W2022076253 @default.
- W2022076253 hasRelatedWork W2025379357 @default.
- W2022076253 hasRelatedWork W2038012085 @default.
- W2022076253 hasRelatedWork W2044885942 @default.
- W2022076253 hasRelatedWork W2048812543 @default.
- W2022076253 hasRelatedWork W2079708404 @default.
- W2022076253 hasRelatedWork W2094867358 @default.
- W2022076253 hasRelatedWork W2096836121 @default.
- W2022076253 hasRelatedWork W2160355439 @default.
- W2022076253 hasVolume "22" @default.
- W2022076253 isParatext "false" @default.
- W2022076253 isRetracted "false" @default.
- W2022076253 magId "2022076253" @default.
- W2022076253 workType "article" @default.