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• W2022079416 abstract "Gamma interferon (IFN-γ) production by peripheral blood mononuclear cells (PBM) was measured in 21 patients with Crohn's disease, in 15 patients with ulcerative colitis, in 12 patients with non-IBD gastrointestinal disease (disease control), and in 28 healthy controls. T-cell subset proportions and serum levels of thymosin α1 and thymosin β4, two hormonelike thymic peptides, were also determined. No differences were seen in T-cell subset proportions in patients with Crohn's disease or ulcerative colitis when compared to healthy controls or to the disease-control group. In vitro IFN-γ production was markedly decreased in Crohn's disease and in untreated, but not treated, patients with ulcerative colitis. Preincubation of PBM prior to the addition of inducer mitogen resulted in enhanced IFN-γ production in patients with Crohn's disease or ulcerative colitis which significantly exceeded that seen either in healthy controls or in the disease-control group. Serum thymosin α1 levels were comparable in all study groups; however, serum thymosin β4 concentrations were significantly higher in all patient groups than in the healthy controls. These results confirm a defective in vitro IFN-γ production in patients with IBD which is apparently independent of endocrine thymus regulation." @default.
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• W2022079416 date "1988-04-01" @default.
• W2022079416 modified "2023-09-27" @default.
• W2022079416 title "Defective in vitro gamma interferon production and elevated serum immunoreactive thymosin β4 levels in patients with inflammatory bowel disease" @default.
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• W2022079416 doi "https://doi.org/10.1016/0090-1229(88)90147-x" @default.
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