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- W2022079791 endingPage "307" @default.
- W2022079791 startingPage "297" @default.
- W2022079791 abstract "Genomic stability is maintained by telomeres, the end terminal structures that protect chromosomes from fusion or degradation. Shortening or loss of telomeric repeats or altered telomere chromatin structure is correlated with telomere dysfunction such as chromosome end-to-end associations that could lead to genomic instability and gene amplification. The structure at the end of telomeres is such that its DNA differs from DNA double strand breaks (DSBs) to avoid nonhomologous end-joining (NHEJ), which is accomplished by forming a unique higher order nucleoprotein structure. Telomeres are attached to the nuclear matrix and have a unique chromatin structure. Whether this special structure is maintained by specific chromatin changes is yet to be thoroughly investigated. Chromatin modifications implicated in transcriptional regulation are thought to be the result of a code on the histone proteins (histone code). This code, involving phosphorylation, acetylation, methylation, ubiquitylation, and sumoylation of histones, is believed to regulate chromatin accessibility either by disrupting chromatin contacts or by recruiting non-histone proteins to chromatin. The histone code in which distinct histone tail-protein interactions promote engagement may be the deciding factor for choosing specific DSB repair pathways. Recent evidence suggests that such mechanisms are involved in DNA damage detection and repair. Altered telomere chromatin structure has been linked to defective DNA damage response (DDR), and eukaryotic cells have evolved DDR mechanisms utilizing proficient DNA repair and cell cycle checkpoints in order to maintain genomic stability. Recent studies suggest that chromatin modifying factors play a critical role in the maintenance of genomic stability. This review will summarize the role of DNA damage repair proteins specifically ataxia-telangiectasia mutated (ATM) and its effectors and the telomere complex in maintaining genome stability." @default.
- W2022079791 created "2016-06-24" @default.
- W2022079791 creator A5009449249 @default.
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- W2022079791 creator A5046655975 @default.
- W2022079791 creator A5072630592 @default.
- W2022079791 date "2008-01-01" @default.
- W2022079791 modified "2023-10-10" @default.
- W2022079791 title "Telomeres, histone code, and DNA damage response" @default.
- W2022079791 cites W1480319220 @default.
- W2022079791 cites W1486351605 @default.
- W2022079791 cites W1511815964 @default.
- W2022079791 cites W1520268659 @default.
- W2022079791 cites W1533604650 @default.
- W2022079791 cites W1563743635 @default.
- W2022079791 cites W1569658633 @default.
- W2022079791 cites W1576964011 @default.
- W2022079791 cites W160911776 @default.
- W2022079791 cites W1620981049 @default.
- W2022079791 cites W1625510017 @default.
- W2022079791 cites W1635316621 @default.
- W2022079791 cites W1804841424 @default.
- W2022079791 cites W1842203567 @default.
- W2022079791 cites W1967364632 @default.
- W2022079791 cites W1967803195 @default.
- W2022079791 cites W1970821439 @default.
- W2022079791 cites W1971358935 @default.
- W2022079791 cites W1971708555 @default.
- W2022079791 cites W1973085375 @default.
- W2022079791 cites W1979181676 @default.
- W2022079791 cites W1980695429 @default.
- W2022079791 cites W1984430482 @default.
- W2022079791 cites W1985180051 @default.
- W2022079791 cites W1985679430 @default.
- W2022079791 cites W1987643363 @default.
- W2022079791 cites W1987850577 @default.
- W2022079791 cites W1991125055 @default.
- W2022079791 cites W1992028815 @default.
- W2022079791 cites W1992350296 @default.
- W2022079791 cites W1994577866 @default.
- W2022079791 cites W1994716755 @default.
- W2022079791 cites W1994848650 @default.
- W2022079791 cites W1995796643 @default.
- W2022079791 cites W1997029250 @default.
- W2022079791 cites W1997245966 @default.
- W2022079791 cites W1997439972 @default.
- W2022079791 cites W1999206490 @default.
- W2022079791 cites W2000912535 @default.
- W2022079791 cites W2002698073 @default.
- W2022079791 cites W2008922065 @default.
- W2022079791 cites W2011840262 @default.
- W2022079791 cites W2012245463 @default.
- W2022079791 cites W2014736194 @default.
- W2022079791 cites W2018507091 @default.
- W2022079791 cites W2022324412 @default.
- W2022079791 cites W2022811243 @default.
- W2022079791 cites W2022936129 @default.
- W2022079791 cites W2024877615 @default.
- W2022079791 cites W2029531565 @default.
- W2022079791 cites W2031203839 @default.
- W2022079791 cites W2031863792 @default.
- W2022079791 cites W2034092805 @default.
- W2022079791 cites W2034353458 @default.
- W2022079791 cites W2035574894 @default.
- W2022079791 cites W2035915355 @default.
- W2022079791 cites W2037508254 @default.
- W2022079791 cites W2038451572 @default.
- W2022079791 cites W2038875604 @default.
- W2022079791 cites W2039785798 @default.
- W2022079791 cites W2040506727 @default.
- W2022079791 cites W2041153072 @default.
- W2022079791 cites W2041860345 @default.
- W2022079791 cites W2043682043 @default.
- W2022079791 cites W2046079276 @default.
- W2022079791 cites W2047067007 @default.
- W2022079791 cites W2049896711 @default.
- W2022079791 cites W2050178809 @default.
- W2022079791 cites W2050643804 @default.
- W2022079791 cites W2054501468 @default.
- W2022079791 cites W2062284662 @default.
- W2022079791 cites W2064727462 @default.
- W2022079791 cites W2066774009 @default.
- W2022079791 cites W2068904622 @default.
- W2022079791 cites W2068973408 @default.
- W2022079791 cites W2073658080 @default.
- W2022079791 cites W2077086907 @default.
- W2022079791 cites W2078362264 @default.
- W2022079791 cites W2078465024 @default.
- W2022079791 cites W2078955430 @default.
- W2022079791 cites W2080769506 @default.
- W2022079791 cites W2081091627 @default.
- W2022079791 cites W2081702399 @default.
- W2022079791 cites W2085299836 @default.
- W2022079791 cites W2085461478 @default.
- W2022079791 cites W2085907623 @default.
- W2022079791 cites W2089456325 @default.
- W2022079791 cites W2090311962 @default.
- W2022079791 cites W2090571513 @default.