Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022080291> ?p ?o ?g. }
- W2022080291 endingPage "8175" @default.
- W2022080291 startingPage "8168" @default.
- W2022080291 abstract "Osteocyte viability is a critical determinant of bone strength and is promoted by both mechanical stimulation and activation of the Wnt signaling pathway. Earlier studies demonstrated that both stimuli promote survival of osteocytes by activating the ERKs. Here, we show that there is interaction between the caveolin-1/ERK and Wnt/β-catenin signaling pathways in the transduction of mechanical cues into osteocyte survival. Thus, ERK nuclear translocation and anti-apoptosis induced by mechanical stimulation are abolished by the Wnt antagonist Dkk1 and the β-catenin degradation stimulator Axin2. Conversely, GSK3β phosphorylation and β-catenin accumulation induced by mechanical stimulation are abolished by either pharmacologic inhibition of ERKs or silencing caveolin-1. In contrast, the canonical Wnt signaling inhibitor dominant-negative T cell factor does not alter ERK nuclear translocation or survival induced by mechanical stimulation. These findings demonstrate that β-catenin accumulation is an essential component of the mechanotransduction machinery in osteocytes, albeit β-catenin/T cell factor-mediated transcription is not required. The simultaneous requirement of β-catenin for ERK activation and of ERK activation for β-catenin accumulation suggests a bidirectional crosstalk between the caveolin-1/ERK and Wnt/β-catenin pathways in mechanotransduction leading to osteocyte survival." @default.
- W2022080291 created "2016-06-24" @default.
- W2022080291 creator A5032860185 @default.
- W2022080291 creator A5038743486 @default.
- W2022080291 creator A5053404897 @default.
- W2022080291 creator A5063050383 @default.
- W2022080291 creator A5089412457 @default.
- W2022080291 date "2013-03-01" @default.
- W2022080291 modified "2023-10-05" @default.
- W2022080291 title "Crosstalk between Caveolin-1/Extracellular Signal-regulated Kinase (ERK) and β-Catenin Survival Pathways in Osteocyte Mechanotransduction" @default.
- W2022080291 cites W1635607892 @default.
- W2022080291 cites W1969807770 @default.
- W2022080291 cites W1972009876 @default.
- W2022080291 cites W1976329877 @default.
- W2022080291 cites W1980028312 @default.
- W2022080291 cites W1984199402 @default.
- W2022080291 cites W1984426954 @default.
- W2022080291 cites W1986085728 @default.
- W2022080291 cites W1990495894 @default.
- W2022080291 cites W1991882891 @default.
- W2022080291 cites W1993163869 @default.
- W2022080291 cites W1994518372 @default.
- W2022080291 cites W1995775202 @default.
- W2022080291 cites W1996161852 @default.
- W2022080291 cites W1997364024 @default.
- W2022080291 cites W2001521752 @default.
- W2022080291 cites W2007478852 @default.
- W2022080291 cites W2007854449 @default.
- W2022080291 cites W2013293643 @default.
- W2022080291 cites W2014707010 @default.
- W2022080291 cites W2019582558 @default.
- W2022080291 cites W2020903392 @default.
- W2022080291 cites W2024679248 @default.
- W2022080291 cites W2025827978 @default.
- W2022080291 cites W2036120792 @default.
- W2022080291 cites W2038965450 @default.
- W2022080291 cites W2039223695 @default.
- W2022080291 cites W2041181827 @default.
- W2022080291 cites W2056301653 @default.
- W2022080291 cites W2074898328 @default.
- W2022080291 cites W2088921555 @default.
- W2022080291 cites W2097438933 @default.
- W2022080291 cites W2103737135 @default.
- W2022080291 cites W2111113377 @default.
- W2022080291 cites W2119934014 @default.
- W2022080291 cites W2147864074 @default.
- W2022080291 cites W2152769008 @default.
- W2022080291 cites W2153942451 @default.
- W2022080291 cites W2156753857 @default.
- W2022080291 cites W2166254889 @default.
- W2022080291 cites W2168587822 @default.
- W2022080291 cites W2170680219 @default.
- W2022080291 cites W4241777407 @default.
- W2022080291 doi "https://doi.org/10.1074/jbc.m112.437921" @default.
- W2022080291 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3605635" @default.
- W2022080291 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23362257" @default.
- W2022080291 hasPublicationYear "2013" @default.
- W2022080291 type Work @default.
- W2022080291 sameAs 2022080291 @default.
- W2022080291 citedByCount "59" @default.
- W2022080291 countsByYear W20220802912013 @default.
- W2022080291 countsByYear W20220802912014 @default.
- W2022080291 countsByYear W20220802912015 @default.
- W2022080291 countsByYear W20220802912016 @default.
- W2022080291 countsByYear W20220802912017 @default.
- W2022080291 countsByYear W20220802912018 @default.
- W2022080291 countsByYear W20220802912019 @default.
- W2022080291 countsByYear W20220802912020 @default.
- W2022080291 countsByYear W20220802912021 @default.
- W2022080291 countsByYear W20220802912022 @default.
- W2022080291 countsByYear W20220802912023 @default.
- W2022080291 crossrefType "journal-article" @default.
- W2022080291 hasAuthorship W2022080291A5032860185 @default.
- W2022080291 hasAuthorship W2022080291A5038743486 @default.
- W2022080291 hasAuthorship W2022080291A5053404897 @default.
- W2022080291 hasAuthorship W2022080291A5063050383 @default.
- W2022080291 hasAuthorship W2022080291A5089412457 @default.
- W2022080291 hasBestOaLocation W20220802911 @default.
- W2022080291 hasConcept C120665830 @default.
- W2022080291 hasConcept C121332964 @default.
- W2022080291 hasConcept C137620995 @default.
- W2022080291 hasConcept C169822122 @default.
- W2022080291 hasConcept C181104049 @default.
- W2022080291 hasConcept C184235292 @default.
- W2022080291 hasConcept C185592680 @default.
- W2022080291 hasConcept C202751555 @default.
- W2022080291 hasConcept C2777491412 @default.
- W2022080291 hasConcept C2778260815 @default.
- W2022080291 hasConcept C2779324961 @default.
- W2022080291 hasConcept C2780973866 @default.
- W2022080291 hasConcept C30145163 @default.
- W2022080291 hasConcept C55493867 @default.
- W2022080291 hasConcept C57074206 @default.
- W2022080291 hasConcept C62478195 @default.
- W2022080291 hasConcept C86803240 @default.
- W2022080291 hasConcept C95444343 @default.
- W2022080291 hasConceptScore W2022080291C120665830 @default.
- W2022080291 hasConceptScore W2022080291C121332964 @default.