Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022081686> ?p ?o ?g. }
- W2022081686 endingPage "380" @default.
- W2022081686 startingPage "362" @default.
- W2022081686 abstract "To examine the association between maternal and fetal genetic variants and small-for-gestational-age (SGA).A case-control study was conducted in patients with SGA neonates (530 maternal and 436 fetal) and controls (599 maternal and 628 fetal); 190 candidate genes and 775 SNPs were studied. Single-locus, multi-locus and haplotype association analyses were performed on maternal and fetal data with logistic regression, multifactor dimensionality reduction (MDR) analysis, and haplotype-based association with 2 and 3 marker sliding windows, respectively. Ingenuity pathway analysis (IPA) software was used to assess pathways that associate with SGA.The most significant single-locus association in maternal data was with a SNP in tissue inhibitor of metalloproteinase 2 (TIMP2) (rs2277698 OR = 1.71, 95% CI [1.26-2.32], p = 0.0006) while in the fetus it was with a SNP in fibronectin 1 isoform 3 preproprotein (FN1) (rs3796123, OR = 1.46, 95% CI [1.20-1.78], p = 0.0001). Both SNPs were adjusted for potential confounders (maternal body mass index and fetal sex). Haplotype analyses resulted in associations in α 1 type I collagen preproprotein (COL1A1, rs1007086-rs2141279-rs17639446, global p = 0.006) in mothers and FN1 (rs2304573-rs1250204-rs1250215, global p = 0.045) in fetuses. Multi-locus analyses with MDR identified a two SNP model with maternal variants collagen type V α 2 (COL5A2) and plasminogen activator urokinase (PLAU) predicting SGA outcome correctly 59% of the time (p = 0.035).Genetic variants in extracellular matrix-related genes showed significant single-locus association with SGA. These data are consistent with other studies that have observed elevated circulating fibronectin concentrations in association with increased risk of SGA. The present study supports the hypothesis that DNA variants can partially explain the risk of SGA in a cohort of Hispanic women." @default.
- W2022081686 created "2016-06-24" @default.
- W2022081686 creator A5004844213 @default.
- W2022081686 creator A5005123641 @default.
- W2022081686 creator A5008882125 @default.
- W2022081686 creator A5011726013 @default.
- W2022081686 creator A5012616293 @default.
- W2022081686 creator A5016182502 @default.
- W2022081686 creator A5023825201 @default.
- W2022081686 creator A5032961249 @default.
- W2022081686 creator A5045578843 @default.
- W2022081686 creator A5051477656 @default.
- W2022081686 creator A5056057196 @default.
- W2022081686 creator A5058177577 @default.
- W2022081686 creator A5059225656 @default.
- W2022081686 creator A5062230681 @default.
- W2022081686 creator A5062343681 @default.
- W2022081686 creator A5067511554 @default.
- W2022081686 creator A5071169085 @default.
- W2022081686 creator A5074453205 @default.
- W2022081686 creator A5076980114 @default.
- W2022081686 creator A5084298310 @default.
- W2022081686 creator A5085524384 @default.
- W2022081686 creator A5088172673 @default.
- W2022081686 date "2010-07-09" @default.
- W2022081686 modified "2023-10-04" @default.
- W2022081686 title "Polymorphisms in maternal and fetal genes encoding for proteins involved in extracellular matrix metabolism alter the risk for small-for-gestational-age" @default.
- W2022081686 cites W108658453 @default.
- W2022081686 cites W1532551225 @default.
- W2022081686 cites W1542313985 @default.
- W2022081686 cites W1552362389 @default.
- W2022081686 cites W1564769057 @default.
- W2022081686 cites W1676788251 @default.
- W2022081686 cites W1720024051 @default.
- W2022081686 cites W1772031652 @default.
- W2022081686 cites W1969163685 @default.
- W2022081686 cites W1969755644 @default.
- W2022081686 cites W1977334843 @default.
- W2022081686 cites W1977895998 @default.
- W2022081686 cites W1978635975 @default.
- W2022081686 cites W1980363362 @default.
- W2022081686 cites W1980732045 @default.
- W2022081686 cites W1980761042 @default.
- W2022081686 cites W1981543999 @default.
- W2022081686 cites W1982746338 @default.
- W2022081686 cites W1987960770 @default.
- W2022081686 cites W1988103526 @default.
- W2022081686 cites W1990795537 @default.
- W2022081686 cites W1991959440 @default.
- W2022081686 cites W1992740425 @default.
- W2022081686 cites W1997728425 @default.
- W2022081686 cites W1999035970 @default.
- W2022081686 cites W1999066973 @default.
- W2022081686 cites W2000520991 @default.
- W2022081686 cites W2001260973 @default.
- W2022081686 cites W2001461028 @default.
- W2022081686 cites W2002605005 @default.
- W2022081686 cites W2002730408 @default.
- W2022081686 cites W2006551228 @default.
- W2022081686 cites W2008834520 @default.
- W2022081686 cites W2008849588 @default.
- W2022081686 cites W2009326079 @default.
- W2022081686 cites W2010712475 @default.
- W2022081686 cites W2012376597 @default.
- W2022081686 cites W2013560047 @default.
- W2022081686 cites W2015391784 @default.
- W2022081686 cites W2017758502 @default.
- W2022081686 cites W2022238295 @default.
- W2022081686 cites W2025499382 @default.
- W2022081686 cites W2025796564 @default.
- W2022081686 cites W2025869885 @default.
- W2022081686 cites W2027813788 @default.
- W2022081686 cites W2029405522 @default.
- W2022081686 cites W2029422699 @default.
- W2022081686 cites W2031220469 @default.
- W2022081686 cites W2031621454 @default.
- W2022081686 cites W2032169940 @default.
- W2022081686 cites W2034267806 @default.
- W2022081686 cites W2034883277 @default.
- W2022081686 cites W2036249825 @default.
- W2022081686 cites W2036421581 @default.
- W2022081686 cites W2037627929 @default.
- W2022081686 cites W2038487326 @default.
- W2022081686 cites W2038688881 @default.
- W2022081686 cites W2040452409 @default.
- W2022081686 cites W2042863269 @default.
- W2022081686 cites W2047994353 @default.
- W2022081686 cites W2051305238 @default.
- W2022081686 cites W2051930892 @default.
- W2022081686 cites W2052233024 @default.
- W2022081686 cites W2052346685 @default.
- W2022081686 cites W2053056528 @default.
- W2022081686 cites W2054083308 @default.
- W2022081686 cites W2054680925 @default.
- W2022081686 cites W2058845341 @default.
- W2022081686 cites W2061535378 @default.
- W2022081686 cites W2062542617 @default.
- W2022081686 cites W2062848322 @default.