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- W2022081947 abstract "Viral infection and acetylsalicylate(ASA)-induced mitochondrial aberration have been reported to play important roles in the pathogenesis of Reye's syndrome. We report that increasing amounts of ASA (0 to 250 μmol/L) resulted in increases in state 4 respiration and decreases in state 3 respiration in rat liver mitochondria in vitro when using α-ketoglutarate and/or β-hydroxybutyrate as respiratory substrates, but not when using succinate as substrate. Interferon alfa (IFN-α) (1.5 to 5 × 104IU/mL, ∼ the therapeutic dosage for humans) and interleukin-1 (IL-1) (1.5 to 2 × 104IU/mL, nearly equivalent to the therapeutic dosage) decreased the severity of the above effects via interaction with mitochondrial membranes. Interferon gamma (IFN-γ) and interleukin-2 (IL-2) had no such protective effect. Electron microscopic observation indicated that IFN-α prevented the induction of mitochondrial swelling by ASA. These results suggest that IFN-α may prove to be effective for the treatment of Reye's syndrome." @default.
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- W2022081947 date "1992-08-01" @default.
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- W2022081947 title "Experimental study on Reye's syndrome: Inhibitory effect of interferon alfa on acetylsalicylate-induced injury to rat liver mitochondria" @default.
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- W2022081947 doi "https://doi.org/10.1016/0026-0495(92)90172-7" @default.
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