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- W2022082596 abstract "Diphenylhydantoin and calcium act antagonistically with respect to stimulus-coupled dl-norepinephrine-<sup>3</sup>H (NE<sup>3</sup>H) release from rat brain slices. Diphenylhydantoin also reduced calcium Ca 45 (<sup>45</sup>Ca) uptake into brain tissue. Procaine had a similar effect on NE<sup>3</sup>H release and<sup>45</sup>Ca uptake; (hydroxyphenyl) phenylhydantoin, phenobarbital, and tetrodotoxin had no effect on either. Ouabain increased NE<sup>3</sup>H release and<sup>45</sup>Ca uptake. The NE<sup>3</sup>H release from brain slices was sensitive to other circumstances that affect calcium movement: It was increased in low sodium media and decreased by high magnesium concentrations. These results are compatible with the hypothesis that diphenylhydantoin acts like a local anesthetic and primarily limits membrane permeability to calcium." @default.
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- W2022082596 title "Diphenylhydantoin and Calcium" @default.
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- W2022082596 doi "https://doi.org/10.1001/archneur.1973.00490280051007" @default.
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