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- W2022082598 abstract "Purpose: Turbulent flow just distal to stenoses causes signal loss (dephasing) on magnetic resonance angiography (MRA). This study correlates dephasing with trans-stenotic pressure gradients in an in vitro model of arterial stenosis. Materials and methods: Three-dimensional (3D) phase contrast, 2D time-of-flight, and 3D spoiled gradient echo MRA with/without gadolinium and varied echo time were performed for a system consisting of a peristaltic perfusion pump and a silastic vessel with stenoses of varying caliber. Length and diameter of dephasing jets were measured, and volumes calculated at varying pressure gradients and echo times, then correlated with percentage cross-sectional area stenosis as measured by conventional angiography. Results: Dephasing occurred in all sequences at pressure gradients of ≥4 mmHg (1 mmHg = 133 Pa) and stenoses of greater than 70%, and varied directly with pressure gradient. The dephasing was greatest for 3D phase contrast (PC). Gadolinium did not diminish dephasing. Conclusions: MRA signal dephasing at stenoses varies directly with pressure gradient. MRA may provide a non-invasive means for determining the hemodynamic significance of arterial stenoses." @default.
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- W2022082598 date "1998-04-01" @default.
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- W2022082598 title "In Vitro Model of Arterial Stenosis: Correlation of MR Signal Dephasing and Trans-Stenotic Pressure Gradients" @default.
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- W2022082598 doi "https://doi.org/10.1016/s0730-725x(97)00304-4" @default.
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