FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022082634> ?p ?o ?g. }

• W2022082634 endingPage "150" @default.
• W2022082634 startingPage "143" @default.
• W2022082634 abstract "N-cadherin and beta1-integrin adhesion and signaling play important roles in growth cone adhesion and guidance. Each of these adhesion receptor systems is composed of multiprotein complexes, and both adhesion and downstream signaling events are regulated through the interaction of protein tyrosine kinases and phosphatases with many of the proteins that make up these complex systems. Work from our laboratory reported that the nonreceptor protein tyrosine phosphatase PTP1B is localized to adherens junctions and focal adhesion complexes and regulates both N-cadherin- and beta1-integrin-mediated adhesion. PTP1B appears to modulate integrin-mediated adhesion through regulation of src activation and cadherin-mediated adhesion through dephosphorylation of beta-catenin. We have continued these studies and report that PTP1B is localized to the tips of growing neurites and that introduction of a noncatalytic mutant of PTP1B into PC12 cells results in inhibition of N-cadherin- and beta1-integrin-mediated neurite outgrowth but is without effect on neurite outgrowth on poly-L-lysine. Moreover, suppressing the level of PTP1B in primary embryonic chick neural retina cells using antisense oligonucleotides also inhibits N-cadherin- and beta1-integrin-mediated neurite outgrowth. Neither of these techniques reduces the levels of expression of either adhesion receptor. We conclude that PTP1B is a regulatory component of the molecular complex required for both N-cadherin and beta1-integrin-mediated axon growth." @default.
• W2022082634 created "2016-06-24" @default.
• W2022082634 creator A5009346937 @default.
• W2022082634 creator A5022050220 @default.
• W2022082634 creator A5030986126 @default.
• W2022082634 creator A5053026352 @default.
• W2022082634 creator A5053725552 @default.
• W2022082634 creator A5058940124 @default.
• W2022082634 creator A5073844142 @default.
• W2022082634 date "2001-01-01" @default.
• W2022082634 modified "2023-09-24" @default.
• W2022082634 title "PTP1B regulates neurite extension mediated by cell-cell and cell-matrix adhesion molecules" @default.
• W2022082634 cites W1487264337 @default.
• W2022082634 cites W1510900532 @default.
• W2022082634 cites W1527739697 @default.
• W2022082634 cites W1570804920 @default.
• W2022082634 cites W169729822 @default.
• W2022082634 cites W1836212818 @default.
• W2022082634 cites W1967203969 @default.
• W2022082634 cites W1973746811 @default.
• W2022082634 cites W1977158130 @default.
• W2022082634 cites W1989326196 @default.
• W2022082634 cites W1998003616 @default.
• W2022082634 cites W2006705432 @default.
• W2022082634 cites W2007753614 @default.
• W2022082634 cites W2009228596 @default.
• W2022082634 cites W2014694962 @default.
• W2022082634 cites W2027980005 @default.
• W2022082634 cites W2029723738 @default.
• W2022082634 cites W2037291219 @default.
• W2022082634 cites W2047471344 @default.
• W2022082634 cites W2053544216 @default.
• W2022082634 cites W2054192585 @default.
• W2022082634 cites W2055354269 @default.
• W2022082634 cites W2059044084 @default.
• W2022082634 cites W2069526456 @default.
• W2022082634 cites W2076457965 @default.
• W2022082634 cites W2082828361 @default.
• W2022082634 cites W2085294978 @default.
• W2022082634 cites W2090901060 @default.
• W2022082634 cites W2094847284 @default.
• W2022082634 cites W2114329786 @default.
• W2022082634 cites W2119609292 @default.
• W2022082634 cites W2123229219 @default.
• W2022082634 cites W2123575778 @default.
• W2022082634 cites W2128810146 @default.
• W2022082634 cites W2134884900 @default.
• W2022082634 cites W2150630317 @default.
• W2022082634 cites W2153556389 @default.
• W2022082634 cites W2164240843 @default.
• W2022082634 cites W2167309932 @default.
• W2022082634 cites W2409357541 @default.
• W2022082634 cites W963887890 @default.
• W2022082634 doi "https://doi.org/10.1002/1097-4547(20010115)63:2<143::aid-jnr1006>3.0.co;2-1" @default.
• W2022082634 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11169624" @default.
• W2022082634 hasPublicationYear "2001" @default.
• W2022082634 type Work @default.
• W2022082634 sameAs 2022082634 @default.
• W2022082634 citedByCount "47" @default.
• W2022082634 countsByYear W20220826342012 @default.
• W2022082634 countsByYear W20220826342013 @default.
• W2022082634 countsByYear W20220826342014 @default.
• W2022082634 countsByYear W20220826342015 @default.
• W2022082634 countsByYear W20220826342016 @default.
• W2022082634 countsByYear W20220826342021 @default.
• W2022082634 crossrefType "journal-article" @default.
• W2022082634 hasAuthorship W2022082634A5009346937 @default.
• W2022082634 hasAuthorship W2022082634A5022050220 @default.
• W2022082634 hasAuthorship W2022082634A5030986126 @default.
• W2022082634 hasAuthorship W2022082634A5053026352 @default.
• W2022082634 hasAuthorship W2022082634A5053725552 @default.
• W2022082634 hasAuthorship W2022082634A5058940124 @default.
• W2022082634 hasAuthorship W2022082634A5073844142 @default.
• W2022082634 hasConcept C113246987 @default.
• W2022082634 hasConcept C122871604 @default.
• W2022082634 hasConcept C135903288 @default.
• W2022082634 hasConcept C1491633281 @default.
• W2022082634 hasConcept C149402561 @default.
• W2022082634 hasConcept C151166631 @default.
• W2022082634 hasConcept C16224149 @default.
• W2022082634 hasConcept C170493617 @default.
• W2022082634 hasConcept C178790620 @default.
• W2022082634 hasConcept C185592680 @default.
• W2022082634 hasConcept C195687474 @default.
• W2022082634 hasConcept C202751555 @default.
• W2022082634 hasConcept C2777553839 @default.
• W2022082634 hasConcept C2779530196 @default.
• W2022082634 hasConcept C55493867 @default.
• W2022082634 hasConcept C62478195 @default.
• W2022082634 hasConcept C84416704 @default.
• W2022082634 hasConcept C85528070 @default.
• W2022082634 hasConcept C85789140 @default.
• W2022082634 hasConcept C86803240 @default.
• W2022082634 hasConcept C95444343 @default.
• W2022082634 hasConceptScore W2022082634C113246987 @default.
• W2022082634 hasConceptScore W2022082634C122871604 @default.
• W2022082634 hasConceptScore W2022082634C135903288 @default.
• W2022082634 hasConceptScore W2022082634C1491633281 @default.

• next