Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022084212> ?p ?o ?g. }
- W2022084212 endingPage "540" @default.
- W2022084212 startingPage "528" @default.
- W2022084212 abstract "A solid self-nanoemulsifying drug-delivery system (solid SNEDDS) has been explored to improve the solubility and dissolution profile of glipizide. SNEDDS preconcentrate was systematically optimized using a circumscribed central composite design by varying Captex 355 (Oil), Solutol HS15 (Surfactant) and Imwitor 988 (Co-surfactant). The optimized SNEDDS preconcentrate consisted of Captex 355 (30% w/w), Solutol HS15 (45% w/w) and Imwitor 988 (25% w/w). The saturation solubility (SS) of glipizide in optimized SNEDDS preconcentrate was found to be 45.12 ± 1.36 mg/ml, indicating an improvement (1367 times) of glipizide solubility as compared to its aqueous solubility (0.033 ± 0.0021 mg/ml). At 90% SS, glipizide was loaded to the optimized SNEDDS. In-vitro dilution of liquid SNEDDS resulted in a nanoemulsion with a mean droplet size of 29.4 nm. TEM studies of diluted liquid SNEDDS confirmed the uniform shape and size of the globules. The liquid SNEDDS was adsorbed onto calcium carbonate and talc to form solid SNEDDS. PXRD, DSC, and SEM results indicated that, the presence of glipizide as an amorphous and as a molecular dispersion state within solid SNEDDS. Glipizide dissolution improved significantly (p < 0.001) from the solid SNEDDS (∼100% in 15 min) as compared to the pure drug (18.37%) and commercial product (65.82) respectively." @default.
- W2022084212 created "2016-06-24" @default.
- W2022084212 creator A5010322978 @default.
- W2022084212 creator A5031730258 @default.
- W2022084212 creator A5047866726 @default.
- W2022084212 creator A5069753892 @default.
- W2022084212 date "2015-10-01" @default.
- W2022084212 modified "2023-09-30" @default.
- W2022084212 title "Design, optimization and evaluation of glipizide solid self-nanoemulsifying drug delivery for enhanced solubility and dissolution" @default.
- W2022084212 cites W1599411444 @default.
- W2022084212 cites W1964209583 @default.
- W2022084212 cites W1967773336 @default.
- W2022084212 cites W1968098666 @default.
- W2022084212 cites W1981081691 @default.
- W2022084212 cites W1986607980 @default.
- W2022084212 cites W1990507034 @default.
- W2022084212 cites W1991622083 @default.
- W2022084212 cites W2000509451 @default.
- W2022084212 cites W2011068615 @default.
- W2022084212 cites W2025265553 @default.
- W2022084212 cites W2030781379 @default.
- W2022084212 cites W2032439697 @default.
- W2022084212 cites W2038322578 @default.
- W2022084212 cites W2041016731 @default.
- W2022084212 cites W2055576047 @default.
- W2022084212 cites W2056995570 @default.
- W2022084212 cites W2064681790 @default.
- W2022084212 cites W2065856359 @default.
- W2022084212 cites W2066645438 @default.
- W2022084212 cites W2066927092 @default.
- W2022084212 cites W2069983835 @default.
- W2022084212 cites W2074207007 @default.
- W2022084212 cites W2075379117 @default.
- W2022084212 cites W2076216132 @default.
- W2022084212 cites W2082382445 @default.
- W2022084212 cites W2083796174 @default.
- W2022084212 cites W2084604144 @default.
- W2022084212 cites W2086660103 @default.
- W2022084212 cites W2087545318 @default.
- W2022084212 cites W2089926889 @default.
- W2022084212 cites W2090417702 @default.
- W2022084212 cites W2094332572 @default.
- W2022084212 cites W2099139094 @default.
- W2022084212 cites W2110769145 @default.
- W2022084212 cites W2124160014 @default.
- W2022084212 cites W2138222053 @default.
- W2022084212 cites W2164690076 @default.
- W2022084212 cites W2166547808 @default.
- W2022084212 cites W2171497934 @default.
- W2022084212 cites W2369136267 @default.
- W2022084212 cites W2417778234 @default.
- W2022084212 doi "https://doi.org/10.1016/j.jsps.2015.01.024" @default.
- W2022084212 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4605912" @default.
- W2022084212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26594119" @default.
- W2022084212 hasPublicationYear "2015" @default.
- W2022084212 type Work @default.
- W2022084212 sameAs 2022084212 @default.
- W2022084212 citedByCount "73" @default.
- W2022084212 countsByYear W20220842122015 @default.
- W2022084212 countsByYear W20220842122016 @default.
- W2022084212 countsByYear W20220842122017 @default.
- W2022084212 countsByYear W20220842122018 @default.
- W2022084212 countsByYear W20220842122019 @default.
- W2022084212 countsByYear W20220842122020 @default.
- W2022084212 countsByYear W20220842122021 @default.
- W2022084212 countsByYear W20220842122022 @default.
- W2022084212 countsByYear W20220842122023 @default.
- W2022084212 crossrefType "journal-article" @default.
- W2022084212 hasAuthorship W2022084212A5010322978 @default.
- W2022084212 hasAuthorship W2022084212A5031730258 @default.
- W2022084212 hasAuthorship W2022084212A5047866726 @default.
- W2022084212 hasAuthorship W2022084212A5069753892 @default.
- W2022084212 hasBestOaLocation W20220842121 @default.
- W2022084212 hasConcept C134018914 @default.
- W2022084212 hasConcept C155574463 @default.
- W2022084212 hasConcept C178790620 @default.
- W2022084212 hasConcept C181389837 @default.
- W2022084212 hasConcept C185592680 @default.
- W2022084212 hasConcept C192562407 @default.
- W2022084212 hasConcept C2779555806 @default.
- W2022084212 hasConcept C2779820397 @default.
- W2022084212 hasConcept C43617362 @default.
- W2022084212 hasConcept C55493867 @default.
- W2022084212 hasConcept C555293320 @default.
- W2022084212 hasConcept C58226133 @default.
- W2022084212 hasConcept C71924100 @default.
- W2022084212 hasConcept C88380143 @default.
- W2022084212 hasConcept C98274493 @default.
- W2022084212 hasConceptScore W2022084212C134018914 @default.
- W2022084212 hasConceptScore W2022084212C155574463 @default.
- W2022084212 hasConceptScore W2022084212C178790620 @default.
- W2022084212 hasConceptScore W2022084212C181389837 @default.
- W2022084212 hasConceptScore W2022084212C185592680 @default.
- W2022084212 hasConceptScore W2022084212C192562407 @default.
- W2022084212 hasConceptScore W2022084212C2779555806 @default.
- W2022084212 hasConceptScore W2022084212C2779820397 @default.
- W2022084212 hasConceptScore W2022084212C43617362 @default.
- W2022084212 hasConceptScore W2022084212C55493867 @default.