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- W2022084713 abstract "Dominant frequency reflects the peak cycle length of atrial fibrillation . In 34 patients with atrial fibrillation, bipolar electrograms were recorded from multiple atrial sites and pulmonary veins and the effect of pilsicainide , class Ic antiarrhythmic drug , on dominant frequency was examined. At baseline, mean dominant frequencies (Hz) in the right and left atria, coronary sinus and right and left superior pulmonary veins were 5.87 ± 0.76, 6.08 ± 0.60, 5.65 ±0.95, 6.12 ± 0.88 and 6.59 ± 0.89, respectively ( P < 0.05, left superior pulmonary vein vs right atrium and coronary sinus). After pilsicainide (1.0 mg/kg/5 min), dominant frequency decreased at all sites in all patients. Atrial fibrillation was terminated at 5.9 ± 2.2 min in 16 patients (Group A) with a decrease in the average of mean dominant frequencies at all sites from 5.80 ± 0.72 to 3.57 ± 0.63 Hz, was converted to atrial flutter at 7.3 ± 1.4 min in 5 (Group B) with a decrease in the average dominant frequency from 5.83 ± 0.48 to 3.08 ± 0.19 Hz, and was not terminated in the other 13 (Group C) despite the average dominant frequency decrease from 6.59 ± 0.76 to 4.42 ± 0.52 Hz. In 14 of the 21 Groups A and B patients (67%), mean dominant frequencies at all recording sites were < 4.0 after pilsicainide, while they were < 4.0 in 1 of the 13 Group C patients (8%, P < 0.01). In conclusion, the degree of dominant frequency decrease by pilsicainide is closely related to its atrial fibrillation terminating effect: When dominant frequency in the atria decreases to < 4.0 Hz, atrial fibrillation is terminated with 93% positive and 63% negative predictive values." @default.
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- W2022084713 date "2009-04-01" @default.
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- W2022084713 title "Effect of pilsicainide on dominant frequency in the right and left atria and pulmonary veins during atrial fibrillation: Association with its atrial fibrillation terminating effect" @default.
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- W2022084713 doi "https://doi.org/10.1016/j.ejphar.2009.02.040" @default.
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