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• W2022085208 abstract "Abstract Background: In contrast to wild type, interleukin‐10‐deficient (IL‐10 −/– ) mice are able to clear Helicobacter infection. In this study, we investigated the immune response of IL‐10 −/– mice leading to the reduction of Helicobacter infection. Materials and Methods: We characterized the immune responses of Helicobacter felis ‐infected IL‐10 −/– mice by studying the systemic antibody and cellular responses toward Helicobacter . We investigated the role of CD4 + T cells in the Helicobacter clearance by injecting H. felis ‐infected IL‐10 −/– mice with anti‐CD4 depleting antibodies. To examine the role of mast cells in Helicobacter clearance, we constructed and infected mast cells and IL‐10 double‐deficient mice. Results: Reduction of Helicobacter infection in IL‐10 −/– mice is associated with strong humoral (fivefold higher serum antiurease antibody titers were measured in IL‐10 −/– in comparison to wild‐type mice, p < .008) and cellular (urease‐stimulated splenic CD4 + T cells isolated from infected IL‐10 −/– mice produce 150‐fold more interferon‐γ in comparison to wild‐type counterparts, p < .008) immune responses directed toward Helicobacter. Depletion of CD4 + cells from Helicobacter ‐infected IL‐10 −/– mice lead to the loss of bacterial clearance (rapid urease tests are threefold higher in CD4 + depleted IL‐10 −/– in comparison to nondepleted IL‐10 −/– mice, p < .02). Mast cell IL‐10 −/– double‐deficient mice clear H. felis infection, indicating that mast cells are unnecessary for the bacterial eradication in IL‐10 −/– mice. Conclusion: Taken together, these results suggest that CD4 + cells are required for Helicobacter clearance in IL‐10 −/– mice. This reduction of Helicobacter infection is, however, not dependent on the mast cell population." @default.
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• W2022085208 date "2008-08-13" @default.
• W2022085208 modified "2023-10-15" @default.
• W2022085208 title "Reduction of<i>Helicobacter</i>Infection in IL-10^−/-Mice is Dependent On CD4⁺T Cells but not on Mast Cells" @default.
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• W2022085208 doi "https://doi.org/10.1111/j.1523-5378.2008.00614.x" @default.
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