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- W2022086637 abstract "Long-term potentiation (LTP) is activity-dependent enhancement of synaptic strength that can critically regulate long-term memory storage. Like memory, LTP exhibits at least two mechanistically distinct temporal phases. Early LTP (E-LTP) does not require protein synthesis, whereas the late phase of LTP (L-LTP), like long-term memory, requires protein synthesis. Hippocampal β-adrenergic receptors can regulate expression of both E-LTP and long-term memory. Although β-adrenergic receptor activation enhances the ability of subthreshold stimuli to induce E-LTP, it is unclear whether such activation can facilitate induction of L-LTP. Here, we use electrophysiological recording methods on mouse hippocampal slices to show that when synaptic stimulation that is subthreshold for inducing L-LTP is paired with β-adrenergic receptor activation, the resulting LTP persists for over 6 h in area CA1. Like L-LTP induced by multiple trains of high-frequency electrical stimulation, this LTP requires protein synthesis. Unlike tetanus-induced L-LTP, however, L-LTP induced by β-adrenergic receptor activation during subthreshold stimulation appears to involve dendritic protein synthesis but not somatic transcription. Maintenance of this LTP also requires activation of extracellular signal-regulated kinases (ERKs). Thus, β-adrenergic receptor activation elicits a type of L-LTP that requires translation and ERK activation but not transcription. This form of L-LTP may be a cellular mechanism for facilitation of behavioral long-term memory during periods of heightened emotional arousal that engage the noradrenergic modulatory system." @default.
- W2022086637 created "2016-06-24" @default.
- W2022086637 creator A5019062257 @default.
- W2022086637 creator A5042163149 @default.
- W2022086637 date "2005-03-30" @default.
- W2022086637 modified "2023-10-11" @default.
- W2022086637 title "β-Adrenergic Receptor Activation Facilitates Induction of a Protein Synthesis-Dependent Late Phase of Long-Term Potentiation" @default.
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- W2022086637 doi "https://doi.org/10.1523/jneurosci.4175-04.2005" @default.
- W2022086637 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6724894" @default.
- W2022086637 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15800184" @default.