FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022086853> ?p ?o ?g. }

• W2022086853 endingPage "S10" @default.
• W2022086853 startingPage "S10" @default.
• W2022086853 abstract "Degeneration of the striatum can occur in multiple disorders with devastating consequences for the patients. Infantile infections with streptococcus, measles, or herpes can cause striatal necrosis associated with dystonia or dyskinesia; and in patients with Huntington's disease the striatum undergoes massive degeneration, leading to behavioral, psychological and movement issues, ultimately resulting in death. Currently, only supportive therapies are available for striatal degeneration. Clinical trials have shown some efficacy using transplantation of fetal-derived primary striatal progenitors. Large banks of fetal progenitors that give rise to medium spiny neurons (MSNs), the primary neuron of the striatum, are needed to make transplantation therapy a reality. However, fetal tissue is of limited supply, has ethical concerns, and is at risk of graft immunorejection. An alternative potential source of MSNs is induced pluripotent stem cells (iPSCs), adult somatic tissues reprogrammed back to a stem cell fate. Multiple publications have demonstrated the ability to differentiate striatal MSNs from iPSCs.Previous publications have demonstrated that the efficacy of fetal progenitor transplants is critically dependent upon the age of the donor embryo/fetus as well as the age of the transplant recipient. With the advent of iPSC technology, a question that remains unanswered concerns the graft's “age,” which is crucial since transplanting pluripotent cells has an inherent risk of over proliferation and teratoma formation. Therefore, in order to also determine the effect of transplant recipient age on the graft, iPSCs were differentiated to three stages along a striatal differentiation paradigm and transplanted into the striatum of both neonatal and adult immunodeficient mice. This study demonstrated that increased murine transplant-recipient age (adult vs neonate) resulted in decreased graft survival and volume/rostro-caudal spread after six weeks in vivo, regardless of “age” of the cells transplanted. Importantly, this study implicates that the in vivo setting may provide a better neurogenic niche for iPSC-based modeling as compared to the in vitro setting. Together, these results recapitulate findings from fetal striatal progenitor transplantation studies and further demonstrate the influence of the host environment on cellular survival and maturation." @default.
• W2022086853 created "2016-06-24" @default.
• W2022086853 creator A5016339725 @default.
• W2022086853 creator A5017248220 @default.
• W2022086853 date "1981-05-01" @default.
• W2022086853 modified "2023-09-25" @default.
• W2022086853 title "Estradiol regulation of IgA, IgG, and secretory component in the rat uterus" @default.
• W2022086853 doi "https://doi.org/10.1016/0165-0378(81)90076-0" @default.
• W2022086853 hasPublicationYear "1981" @default.
• W2022086853 type Work @default.
• W2022086853 sameAs 2022086853 @default.
• W2022086853 citedByCount "0" @default.
• W2022086853 crossrefType "journal-article" @default.
• W2022086853 hasAuthorship W2022086853A5016339725 @default.
• W2022086853 hasAuthorship W2022086853A5017248220 @default.
• W2022086853 hasConcept C104317684 @default.
• W2022086853 hasConcept C107459253 @default.
• W2022086853 hasConcept C126322002 @default.
• W2022086853 hasConcept C145103041 @default.
• W2022086853 hasConcept C169760540 @default.
• W2022086853 hasConcept C203014093 @default.
• W2022086853 hasConcept C2780062018 @default.
• W2022086853 hasConcept C2911091166 @default.
• W2022086853 hasConcept C513476851 @default.
• W2022086853 hasConcept C55493867 @default.
• W2022086853 hasConcept C71924100 @default.
• W2022086853 hasConcept C86803240 @default.
• W2022086853 hasConceptScore W2022086853C104317684 @default.
• W2022086853 hasConceptScore W2022086853C107459253 @default.
• W2022086853 hasConceptScore W2022086853C126322002 @default.
• W2022086853 hasConceptScore W2022086853C145103041 @default.
• W2022086853 hasConceptScore W2022086853C169760540 @default.
• W2022086853 hasConceptScore W2022086853C203014093 @default.
• W2022086853 hasConceptScore W2022086853C2780062018 @default.
• W2022086853 hasConceptScore W2022086853C2911091166 @default.
• W2022086853 hasConceptScore W2022086853C513476851 @default.
• W2022086853 hasConceptScore W2022086853C55493867 @default.
• W2022086853 hasConceptScore W2022086853C71924100 @default.
• W2022086853 hasConceptScore W2022086853C86803240 @default.
• W2022086853 hasLocation W20220868531 @default.
• W2022086853 hasOpenAccess W2022086853 @default.
• W2022086853 hasPrimaryLocation W20220868531 @default.
• W2022086853 hasRelatedWork W1964980861 @default.
• W2022086853 hasRelatedWork W1967128964 @default.
• W2022086853 hasRelatedWork W1998717175 @default.
• W2022086853 hasRelatedWork W2067807133 @default.
• W2022086853 hasRelatedWork W2085420625 @default.
• W2022086853 hasRelatedWork W2200629936 @default.
• W2022086853 hasRelatedWork W2346421087 @default.
• W2022086853 hasRelatedWork W2390871926 @default.
• W2022086853 hasRelatedWork W3033392486 @default.
• W2022086853 hasRelatedWork W4309231699 @default.
• W2022086853 hasVolume "2" @default.
• W2022086853 isParatext "false" @default.
• W2022086853 isRetracted "false" @default.
• W2022086853 magId "2022086853" @default.
• W2022086853 workType "article" @default.