Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022088202> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2022088202 endingPage "1090" @default.
- W2022088202 startingPage "1083" @default.
- W2022088202 abstract "The confinement of membrane proteins by lipid−lipid interactions into specialized detergent-insoluble membrane (DIM) microdomains has been proposed as a general mechanism to recruit selectively lipid-modified proteins and specific transmembrane proteins. Poliovirus capsid VP4 protein and its precursors are myristoylated at the NH2-terminal Gly residue. To determine whether poliovirus uses DIMs during its replicative cycle, we isolated DIMs from poliovirus-infected HeLa cells and identified the presence of capsid proteins and their precursors, proteinases 2A and 3C, and other viral proteins involved in poliovirus RNA replication such as protein 2C and the polymerase 3D. The morphology of these DIMs was similar to that of the previously described rosettelike vesicles associated with replication complexes isolated from poliovirus-infected cells. To examine the possible role of the myristoyl moiety in the targeting of poliovirus structural proteins to DIMs, we generated a chimeric protein consisting of the nine amino-terminal amino acids from VP4 fused to the amino terminus of the green fluorescent protein (GFP). The selected VP4 sequence was sufficient to confer N-myristoylation and targeting to DIMs to the GFP chimera. Mutations within this sequence known to affect both myristoylation and poliovirus assembly abrogated the targeting of the GFP chimera. These results indicate that the myristoylated amino-terminal nonapeptide from poliovirus VP4 protein constitutes a signal for incorporation into DIMs." @default.
- W2022088202 created "2016-06-24" @default.
- W2022088202 creator A5011345655 @default.
- W2022088202 creator A5023973233 @default.
- W2022088202 creator A5029589704 @default.
- W2022088202 creator A5088092328 @default.
- W2022088202 date "2000-01-13" @default.
- W2022088202 modified "2023-10-16" @default.
- W2022088202 title "The Amino-Terminal Nine Amino Acid Sequence of Poliovirus Capsid VP4 Protein Is Sufficient To Confer N-Myristoylation and Targeting to Detergent-Insoluble Membranes†" @default.
- W2022088202 cites W1257336135 @default.
- W2022088202 cites W1538266147 @default.
- W2022088202 cites W1541696172 @default.
- W2022088202 cites W1556270435 @default.
- W2022088202 cites W1632068188 @default.
- W2022088202 cites W1958494624 @default.
- W2022088202 cites W1975815423 @default.
- W2022088202 cites W1989924978 @default.
- W2022088202 cites W2085621575 @default.
- W2022088202 cites W2092312794 @default.
- W2022088202 cites W2121255902 @default.
- W2022088202 cites W2136452042 @default.
- W2022088202 cites W2139846514 @default.
- W2022088202 cites W2144760773 @default.
- W2022088202 cites W2169803769 @default.
- W2022088202 cites W2170385301 @default.
- W2022088202 cites W2238228203 @default.
- W2022088202 cites W96478372 @default.
- W2022088202 doi "https://doi.org/10.1021/bi992132e" @default.
- W2022088202 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10653654" @default.
- W2022088202 hasPublicationYear "2000" @default.
- W2022088202 type Work @default.
- W2022088202 sameAs 2022088202 @default.
- W2022088202 citedByCount "26" @default.
- W2022088202 countsByYear W20220882022013 @default.
- W2022088202 countsByYear W20220882022014 @default.
- W2022088202 countsByYear W20220882022018 @default.
- W2022088202 countsByYear W20220882022019 @default.
- W2022088202 countsByYear W20220882022020 @default.
- W2022088202 countsByYear W20220882022021 @default.
- W2022088202 countsByYear W20220882022022 @default.
- W2022088202 crossrefType "journal-article" @default.
- W2022088202 hasAuthorship W2022088202A5011345655 @default.
- W2022088202 hasAuthorship W2022088202A5023973233 @default.
- W2022088202 hasAuthorship W2022088202A5029589704 @default.
- W2022088202 hasAuthorship W2022088202A5088092328 @default.
- W2022088202 hasConcept C104317684 @default.
- W2022088202 hasConcept C123894998 @default.
- W2022088202 hasConcept C142613039 @default.
- W2022088202 hasConcept C153911025 @default.
- W2022088202 hasConcept C159047783 @default.
- W2022088202 hasConcept C167625842 @default.
- W2022088202 hasConcept C202878990 @default.
- W2022088202 hasConcept C2522874641 @default.
- W2022088202 hasConcept C2779631682 @default.
- W2022088202 hasConcept C40767141 @default.
- W2022088202 hasConcept C41625074 @default.
- W2022088202 hasConcept C515207424 @default.
- W2022088202 hasConcept C55493867 @default.
- W2022088202 hasConcept C77207865 @default.
- W2022088202 hasConcept C86803240 @default.
- W2022088202 hasConcept C95444343 @default.
- W2022088202 hasConceptScore W2022088202C104317684 @default.
- W2022088202 hasConceptScore W2022088202C123894998 @default.
- W2022088202 hasConceptScore W2022088202C142613039 @default.
- W2022088202 hasConceptScore W2022088202C153911025 @default.
- W2022088202 hasConceptScore W2022088202C159047783 @default.
- W2022088202 hasConceptScore W2022088202C167625842 @default.
- W2022088202 hasConceptScore W2022088202C202878990 @default.
- W2022088202 hasConceptScore W2022088202C2522874641 @default.
- W2022088202 hasConceptScore W2022088202C2779631682 @default.
- W2022088202 hasConceptScore W2022088202C40767141 @default.
- W2022088202 hasConceptScore W2022088202C41625074 @default.
- W2022088202 hasConceptScore W2022088202C515207424 @default.
- W2022088202 hasConceptScore W2022088202C55493867 @default.
- W2022088202 hasConceptScore W2022088202C77207865 @default.
- W2022088202 hasConceptScore W2022088202C86803240 @default.
- W2022088202 hasConceptScore W2022088202C95444343 @default.
- W2022088202 hasIssue "5" @default.
- W2022088202 hasLocation W20220882021 @default.
- W2022088202 hasLocation W20220882022 @default.
- W2022088202 hasOpenAccess W2022088202 @default.
- W2022088202 hasPrimaryLocation W20220882021 @default.
- W2022088202 hasRelatedWork W1556205825 @default.
- W2022088202 hasRelatedWork W1958494624 @default.
- W2022088202 hasRelatedWork W1996390383 @default.
- W2022088202 hasRelatedWork W2001430060 @default.
- W2022088202 hasRelatedWork W2022088202 @default.
- W2022088202 hasRelatedWork W2077964044 @default.
- W2022088202 hasRelatedWork W2085621575 @default.
- W2022088202 hasRelatedWork W2354688522 @default.
- W2022088202 hasRelatedWork W2368863504 @default.
- W2022088202 hasRelatedWork W4300597068 @default.
- W2022088202 hasVolume "39" @default.
- W2022088202 isParatext "false" @default.
- W2022088202 isRetracted "false" @default.
- W2022088202 magId "2022088202" @default.
- W2022088202 workType "article" @default.