Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022088312> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2022088312 endingPage "263" @default.
- W2022088312 startingPage "255" @default.
- W2022088312 abstract "The inhibition of protein synthesis that occurs when rabbit reticulocyte lysate is incubated in the absence of hemin is due to the activation of a protein kinase termed the hemin-controlled translational repressor, and that occurring when reticulocyte lysate is incubated with a low level of double-stranded RNA is mediated by the activation of a separate protein kinase termed the double-stranded RNA-activated inhibitor. Both the hemin-controlled translational repressor and the double-stranded RNA-activated inhibitor act by phosphorylating the Mr = 35,000 (alpha) subunit of eIF-2. MnCl2 (0.5 mM) partly reverses the inhibition of protein synthesis produced by hemin deficiency but not that induced by double-stranded RNA. In addition, Mn2+ reverses the inhibition of binding of [35S]Met-tRNAf to reticulocyte ribosomal components, isolated on Sepharose 6B, produced by the hemin-controlled translational repressor but not by the double-stranded RNA-activated inhibitor. The effect of Mn2+ is mediated at the level of activation and eIF-2 alpha kinase activity of these two regulatory protein kinases. Specifically, Mn2+ inhibits activation of the hemin-controlled translational repressor in the absence of hemin and the phosphorylation of eIF-2 alpha by pre-activated translational repressor. In contrast, the phosphorylation of eIF-2 alpha by the double-stranded RNA-activated inhibitor is not suppressed by Mn2+, and the activation and autophosphorylation of this inhibitor is enhanced by Mn2+. Finally, while the activation and inactivation of the hemin-controlled translational repressor does not appear to be mediated by autophosphorylation and dephosphorylation, the activation of the double-stranded RNA-activated inhibitor does appear to require autophosphorylation." @default.
- W2022088312 created "2016-06-24" @default.
- W2022088312 creator A5021721465 @default.
- W2022088312 creator A5053579827 @default.
- W2022088312 date "1983-08-01" @default.
- W2022088312 modified "2023-09-27" @default.
- W2022088312 title "Differential effect of Mn2+ on the hemin-controlled translational repressor and the double-stranded RNA-activated inhibitor" @default.
- W2022088312 cites W103081912 @default.
- W2022088312 cites W1238743721 @default.
- W2022088312 cites W1543884867 @default.
- W2022088312 cites W1574158932 @default.
- W2022088312 cites W1605422079 @default.
- W2022088312 cites W17120247 @default.
- W2022088312 cites W1965116617 @default.
- W2022088312 cites W1965751321 @default.
- W2022088312 cites W1968719690 @default.
- W2022088312 cites W1988219295 @default.
- W2022088312 cites W2003782814 @default.
- W2022088312 cites W2008698899 @default.
- W2022088312 cites W2016407154 @default.
- W2022088312 cites W2017595667 @default.
- W2022088312 cites W2019715256 @default.
- W2022088312 cites W2022721903 @default.
- W2022088312 cites W2037168957 @default.
- W2022088312 cites W2042668209 @default.
- W2022088312 cites W2057272748 @default.
- W2022088312 cites W2062417484 @default.
- W2022088312 cites W2062548975 @default.
- W2022088312 cites W2075701926 @default.
- W2022088312 cites W2085627848 @default.
- W2022088312 cites W2088987839 @default.
- W2022088312 cites W2169255375 @default.
- W2022088312 cites W2217080092 @default.
- W2022088312 cites W51463557 @default.
- W2022088312 cites W613881627 @default.
- W2022088312 doi "https://doi.org/10.1016/0167-4781(83)90134-3" @default.
- W2022088312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6871224" @default.
- W2022088312 hasPublicationYear "1983" @default.
- W2022088312 type Work @default.
- W2022088312 sameAs 2022088312 @default.
- W2022088312 citedByCount "21" @default.
- W2022088312 countsByYear W20220883122021 @default.
- W2022088312 crossrefType "journal-article" @default.
- W2022088312 hasAuthorship W2022088312A5021721465 @default.
- W2022088312 hasAuthorship W2022088312A5053579827 @default.
- W2022088312 hasConcept C104317684 @default.
- W2022088312 hasConcept C11960822 @default.
- W2022088312 hasConcept C150109051 @default.
- W2022088312 hasConcept C150194340 @default.
- W2022088312 hasConcept C153911025 @default.
- W2022088312 hasConcept C158448853 @default.
- W2022088312 hasConcept C181199279 @default.
- W2022088312 hasConcept C185592680 @default.
- W2022088312 hasConcept C2776217839 @default.
- W2022088312 hasConcept C2777723881 @default.
- W2022088312 hasConcept C2778403015 @default.
- W2022088312 hasConcept C3675279 @default.
- W2022088312 hasConcept C55493867 @default.
- W2022088312 hasConcept C67705224 @default.
- W2022088312 hasConcept C86803240 @default.
- W2022088312 hasConcept C97029542 @default.
- W2022088312 hasConceptScore W2022088312C104317684 @default.
- W2022088312 hasConceptScore W2022088312C11960822 @default.
- W2022088312 hasConceptScore W2022088312C150109051 @default.
- W2022088312 hasConceptScore W2022088312C150194340 @default.
- W2022088312 hasConceptScore W2022088312C153911025 @default.
- W2022088312 hasConceptScore W2022088312C158448853 @default.
- W2022088312 hasConceptScore W2022088312C181199279 @default.
- W2022088312 hasConceptScore W2022088312C185592680 @default.
- W2022088312 hasConceptScore W2022088312C2776217839 @default.
- W2022088312 hasConceptScore W2022088312C2777723881 @default.
- W2022088312 hasConceptScore W2022088312C2778403015 @default.
- W2022088312 hasConceptScore W2022088312C3675279 @default.
- W2022088312 hasConceptScore W2022088312C55493867 @default.
- W2022088312 hasConceptScore W2022088312C67705224 @default.
- W2022088312 hasConceptScore W2022088312C86803240 @default.
- W2022088312 hasConceptScore W2022088312C97029542 @default.
- W2022088312 hasIssue "3" @default.
- W2022088312 hasLocation W20220883121 @default.
- W2022088312 hasLocation W20220883122 @default.
- W2022088312 hasOpenAccess W2022088312 @default.
- W2022088312 hasPrimaryLocation W20220883121 @default.
- W2022088312 hasRelatedWork W1965751321 @default.
- W2022088312 hasRelatedWork W1966768816 @default.
- W2022088312 hasRelatedWork W1988219295 @default.
- W2022088312 hasRelatedWork W2022088312 @default.
- W2022088312 hasRelatedWork W2031509361 @default.
- W2022088312 hasRelatedWork W2046489735 @default.
- W2022088312 hasRelatedWork W2085627848 @default.
- W2022088312 hasRelatedWork W2091054968 @default.
- W2022088312 hasRelatedWork W2095461661 @default.
- W2022088312 hasRelatedWork W269312820 @default.
- W2022088312 hasVolume "740" @default.
- W2022088312 isParatext "false" @default.
- W2022088312 isRetracted "false" @default.
- W2022088312 magId "2022088312" @default.
- W2022088312 workType "article" @default.