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- W2022089061 abstract "Purpose: To determine the effect of low intensity laser therapy (LILT) on healing of infected skin wounds in the rat. Methods: Wounds on the dorsum of Sprague-Dawley rats (14 per group) were inoculated or sham-inoculated with P. aeruginosa . Wounds were irradiated or sham-irradiated three times weekly from Day 1-19 using 635nm or 808nm diode lasers at radiant exposure of 1 or 20 J/cm 2 delivered in continuous wave (CW) or at an intensity modulation frequency of 3800Hz. Wound area and bacterial growth were evaluated three times weekly. Results: CW 808 nm (1 and 20 J/cm 2 ) irradiation generally delayed healing in acute wounds. However, from Day 10 onwards CW 808 nm (1 J/cm 2 and 20 J/cm 2 ) and 808 nm 3800 Hz (1 J/cm 2 ) irradiation improved healing in inoculated wounds. Healing in acute wounds improved using 635 nm irradiation at low radiant exposure (1 J/cm 2 ); however, using 635 nm irradiation at high radiant exposure (20 J/cm 2 ) delayed healing. Bacterial balance in wounds was significantly altered using 635 nm (20 J/cm 2 ) and CW 808 nm irradiation (1 and 20 J/cm 2 ). Conclusion: Clearing wounds of normal flora was not associated with improved healing. Proliferation of staphylococcal species in wounds was associated with delayed healing." @default.
- W2022089061 created "2016-06-24" @default.
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- W2022089061 date "2006-02-09" @default.
- W2022089061 modified "2023-09-23" @default.
- W2022089061 title "Effects of low intensity laser irradiation during healing of infected skin lesions in the rat" @default.
- W2022089061 doi "https://doi.org/10.1117/12.647166" @default.
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