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- W2022090503 abstract "Contractile dysfunction of atria and atrial arrhythmias are common comorbidities in heart failure (HF). Although abnormal Ca handling has been recognized to underlie both reduced contractility and increased propensity to arrhythmias in failing left ventricle, its role in HF-related atrial pathogenesis is not well established. We studied Ca handling in control and HF myocytes isolated from left atrial appendage using canine model of chronic heart failure. In this model, chronic HF was associated with reduced left atrial contractility, increased inducibility of atrial fibrillation, and shortened atrial action potential. Amplitude of Ca transients and cellular shortening was significantly reduced in field-stimulated myocytes from HF compared to control group. Diminished Ca transients recorded in voltage-clamped HF myocytes were associated with reduced amplitude of the L-type Ca currents and decreased gain of excitation-contraction coupling. HF myocytes displayed spatial segregation of Ca signaling manifested in impaired propagation of Ca transient from surface to the center. Frequency of Ca sparks in permeabilzed myocytes was higher in HF, while sarcoplasmic reticulum (SR) Ca content was similar in both control and HF groups. Despite of the increased functional activity of ryanodine receptors, rate of occurrence of diastolic Ca waves and corresponding delayed after depolarizations recorded in paced intact myocytes in a presence of beta-adrenergic receptor agonist isoproterenol was significantly lower in HF than in controls. We conclude that reduced atrial contractility observed in canine model of chronic HF can be attributed, at least in part, to the decreased efficacy of Ca current to trigger SR Ca release. Furthermore, our cellular data do not support Ca-dependent triggered activity in left atrial appendage as a mechanism for atrial arrhythmia in chronic HF." @default.
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- W2022090503 date "2013-01-01" @default.
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- W2022090503 title "Remodeling of Atrial Ca Handling in Canine Model of Chronic Heart Failure Points to Non-Triggered Mechanisms of Atrial Fibrillation" @default.
- W2022090503 doi "https://doi.org/10.1016/j.bpj.2012.11.1145" @default.
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