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- W2022091103 abstract "The aim of this study was to identify the LH-gonadotroph, aided by histochemical demonstrations of adenylate cyclase and acid phosphatase activities in 60-day-old male rats, after a single 100 micrograms injection of luteinizing hormone-releasing hormone (LH-RH). The results obtained are as follows: 1) Separation of the lysosomes from the large secretion granules in the LH-gonadotroph was accomplished in order to demonstrate acid phosphatase, the marker enzyme of lysosomes. 2) The large granules in the LH-gonadotroph decreased remarkably in number within 5 min after LH-RH injection. 3) A marked and prolonged increase in adenylate cyclase activity was observed on the plasma membrane of the LH-gonadotroph after LH-RH injection; this increase continued up to 30 min. 4) At 60 min after LH-RH injection the small secretion granules began to decrease in number. 5) Losing the large granules due to the LH-RH treatment, the LH-gonadotroph resembled the FSH-gonadotroph. From these observations it appears that the FSH-gonadotroph is an immature or storage state LH-gonadotroph and that it changes from an LH-gonadotroph into an FSH-gonadotroph on the loss of its large secretion granules." @default.
- W2022091103 created "2016-06-24" @default.
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- W2022091103 date "1982-01-01" @default.
- W2022091103 modified "2023-09-23" @default.
- W2022091103 title "Histochemical study of the rat anterior pituitary LH-gonadotroph after administration of luteinizing hormone releasing hormone (LH-RH)" @default.
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- W2022091103 doi "https://doi.org/10.1679/aohc.45.335" @default.
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