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- W2022092530 abstract "Guanine-rich sequences can fold into four-stranded structures of stacked guanine-tetrads, so-called G-quadruplexes (G4). These unique motifs have been extensively studied on the DNA level; however, exploration of the biological roles of G4s at the RNA level is just emerging. Here we show that G4 RNA when introduced within coding regions are capable of stimulating −1 ribosomal frameshifting (−1 FS) in vitro and in cultured cells. Systematic manipulation of the loop length between each G-tract revealed that the −1 FS efficiency positively correlates with G4 stability. Addition of a G4-stabilizing ligand, PhenDC3, resulted in higher −1 FS. Further, we demonstrated that the G4s can stimulate +1 FS and stop codon readthrough as well. These results suggest a potentially novel translational gene regulation mechanism mediated by G4 RNA." @default.
- W2022092530 created "2016-06-24" @default.
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- W2022092530 date "2013-10-30" @default.
- W2022092530 modified "2023-09-25" @default.
- W2022092530 title "Stimulation of ribosomal frameshifting by RNA G-quadruplex structures" @default.
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- W2022092530 doi "https://doi.org/10.1093/nar/gkt1022" @default.
- W2022092530 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3919603" @default.
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