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- W2022094920 abstract "A natural flexible cyclic molecule, fangchinoline (FAN) from traditional Chinese medicine, was found with a good binding affinity and thermodynamic stabilization effect on a bcl2 G-quadruplex. Further studies showed that fangchinoline could induce the formation and the conformational conversion of G-quadruplexes from a mixed parallel/anti-parallel to a parallel stranded structure. Our study provided a novel G-quadruplex ligand facilitating the structural conversion of the G-quadruplex, which implied that this fangchinoline could be used to regulate biological activities of the G-quadruplex DNA." @default.
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- W2022094920 date "2014-09-12" @default.
- W2022094920 modified "2023-10-16" @default.
- W2022094920 title "Induction of formation and conformational conversion of DNA G-quadruplexes by fangchinoline" @default.
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- W2022094920 doi "https://doi.org/10.1039/c4ay01881h" @default.
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