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• W2022098839 abstract "<b><i>Background: </i></b>The ratio of metastatic to dissected lymph nodes (lymph node ratio; LNR) is a sensitive and superior prognostic factor for lymph node evaluation, but its relationship to cancer subtypes is unclear. <b><i>Patients and Methods: </i></b>Data from 469 patients with axillary lymph node metastasis out of 640 early breast cancer cases were retrospectively analyzed. They were classified into 4 molecular subtypes; luminal A, luminal B HER2(+), HER2 overexpression, basal-like. LNRs were compared between groups and with other prognostic factors. <b><i>Results: </i></b>The distribution of LNRs was 35.2% in luminal A, 43.2% in luminal B HER2(+), 46.9% in HER2 over-expression, and 39.1% in basal-like. A significant difference was found between luminal A and HER2 over-expression subtypes (p = 0.023). LNR was significantly correlated with tumor size and lymphovascular invasion, but not with other prognostic factors including menopausal status, laterality, grade, and perineural invasion. An LNR of 29.8% was defined as the cut-off value, and significant differences in survival rates were identified accordingly between basal-like and both luminal A (p = 0.003) and luminal B HER2(+) (p = 0.04). <b><i>Conclusion: </i></b>The LNR differs between some molecular subtypes of breast cancer, and it correlates with certain prognostic factors and survival. These data support using the LNR to assess breast cancer patients." @default.
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• W2022098839 date "2013-01-01" @default.
• W2022098839 modified "2023-10-16" @default.
• W2022098839 title "Clinical Significance of Lymph Node Ratio in Locally Advanced Breast Cancer Molecular Subtypes" @default.
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• W2022098839 doi "https://doi.org/10.1159/000355663" @default.
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