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• W2022099420 abstract "We and others have shown decreased expression of T-cell receptor-CD3-associated signal transducing ζ molecules (TCRζ) in tumor infiltrating and peripheral T cells of patients with advanced cancer. In the present study, we performed adoptive immunotherapy (AIT) with tumor-associated lymphocytes (TAL) in patients with gastric (n = 11) and colon (n = 3) cancer with stage IV and investigated whether the alteration of signal transducing molecules was observed with AIT, compared to an untreated control group (n = 13). Autologous TALs isolated from malignant ascites or pleural effusion were cultured with stimulation of autologous tumor in the presence of interleukin-2 (IL-2) and were transferred to the patients. TCR ζ expression in peripheral T cells was measured by flow cytometric analysis of permeabilized cells with anti-ζ monoclonal antibody (MAb) (TIA-2) before and after AIT. We confirmed the down-regulation of TCR ζ expression in peripheral blood lymphocytes (PBL) of patients with gastric and colon cancer with stage IV compared to healthy donors (n = 15). AIT induced up-regulation of TCR ζ expression in 2 of 14 treated patients, caused no significant change of TCR ζ expression in 7 patients and induced further down-regulation in 5 patients. The patients who achieved clinical responses (n = 3) with AIT showed no significant change of TCR ζ expression. On the other hand, in the control group without adoptive transfer, further down-regulation of TCR ζ expression was observed during the corresponding periods, paralleling disease progression. Taken together, TCR ζ expression in the patients was further down-regulated, corresponding to disease progression in individual cancer patients. In some patients, AIT could induce increased or stable TCR ζ expression. The quantitative analysis of TCR ζ expression might provide vital information that can be used to optimize therapy by preserving immune functions within cancer patients. Int. J. Cancer 78:301–305, 1998.© 1998 Wiley-Liss, Inc." @default.
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• W2022099420 date "1998-10-29" @default.
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• W2022099420 title "Expression of signal transducing T-cell receptor ζ molecules after adoptive immunotherapy in patients with gastric and colon cancer" @default.
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• W2022099420 doi "https://doi.org/10.1002/(sici)1097-0215(19981029)78:3<301::aid-ijc7>3.0.co;2-z" @default.
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