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- W2022099717 abstract "Abstract A simple and sensitive high performance liquid chromatographic method (HPLC) and direct flow injection analysis method (FIA) are described for the determination of trimetazidine HCl (TMZ) in tablets. A mobile phase consisting of methanol:0.02 mol · L−1 potassium dihydrogen phosphate:0.005 mol · L−1 sodium dihydrogen phosphate (62:5:33 v/v/v) was used for the resolution of the compound on a reversed phase column for HPLC. For the FIA method; the best solvent system was found to be consisting of methanol:water (10:90 v/v). A flow rate of l.2 mL · min−1 was pumped and active material was detected at 210 nm. Limit of detection (LOD) and limit of quantitation (LOQ) values were found to be 1.2×10−7 mol · L−1 and 3.5×10−7 mol · L−1, respectively, for HPLC. LOD and LOQ values were found to be 2.35×10−7 mol · L−1 and 7.04×10−7 mol · L−1, respectively for FIA. The results obtained from the analysis of TMZ tablet formulations were comparable using both methods." @default.
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- W2022099717 date "2006-09-01" @default.
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- W2022099717 title "Rapid HPLC and Direct Flow Injection Analysis Assay for the Determination of Trimetazidine HCl in Pharmaceutical Tablet Formulation" @default.
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- W2022099717 doi "https://doi.org/10.1080/10826070600832921" @default.
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