Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022099770> ?p ?o ?g. }
- W2022099770 endingPage "3158" @default.
- W2022099770 startingPage "3153" @default.
- W2022099770 abstract "Fluorescent light (FL) has been shown to generate free radicals within cells, however, the specific chemical nature of DNA damage induced by FL has not previously been determined. Using gas chromatography/isotope dilution mass spectrometry, we have detected induction of the oxidative DNA lesions 5-hydroxycytosine (5-OH-Cyt), 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) and 4, 6-diamino-5-formamidopyrimidine (FapyAde) in cultured cells irradiated with FL. We followed the repair of these lesions in normal and xeroderma pigmentosum group A (XP-A) cells. 5-OH-Cyt and FapyGua were repaired efficiently in normal cells within 6 h following FL exposure. XP-A cells were unable to repair these oxidative DNA base lesions. Additionally, to compare the repair of oxidative lesions induced by various sources, in vitro repair studies were performed using plasmid DNA damaged by FL, gamma-irradiation or OsO(4)treatment. Whole cell extracts from normal cells repaired damaged substrates efficiently, whereas there was little repair in XP-A extracts. Our data demon-strate defective repair of oxidative DNA base lesions in XP-A cells in vivo and in vitro." @default.
- W2022099770 created "2016-06-24" @default.
- W2022099770 creator A5002170667 @default.
- W2022099770 creator A5012088953 @default.
- W2022099770 creator A5030427664 @default.
- W2022099770 creator A5057306543 @default.
- W2022099770 creator A5063281832 @default.
- W2022099770 creator A5086128602 @default.
- W2022099770 creator A5089917586 @default.
- W2022099770 date "1999-08-01" @default.
- W2022099770 modified "2023-09-24" @default.
- W2022099770 title "Repair of oxidative DNA base lesions induced by fluorescent light is defective in xeroderma pigmentosum group A cells" @default.
- W2022099770 cites W1447315841 @default.
- W2022099770 cites W1845321470 @default.
- W2022099770 cites W1964198669 @default.
- W2022099770 cites W1964434312 @default.
- W2022099770 cites W1968768471 @default.
- W2022099770 cites W1969769040 @default.
- W2022099770 cites W1973511453 @default.
- W2022099770 cites W1976127826 @default.
- W2022099770 cites W1981671408 @default.
- W2022099770 cites W1987303706 @default.
- W2022099770 cites W1989317177 @default.
- W2022099770 cites W1996258759 @default.
- W2022099770 cites W1997476198 @default.
- W2022099770 cites W1999069134 @default.
- W2022099770 cites W2006377201 @default.
- W2022099770 cites W2007998684 @default.
- W2022099770 cites W2011208405 @default.
- W2022099770 cites W2012291005 @default.
- W2022099770 cites W2012300945 @default.
- W2022099770 cites W2012719479 @default.
- W2022099770 cites W2016585187 @default.
- W2022099770 cites W2019777050 @default.
- W2022099770 cites W2023256344 @default.
- W2022099770 cites W2029739205 @default.
- W2022099770 cites W2039158807 @default.
- W2022099770 cites W2049602242 @default.
- W2022099770 cites W2051883249 @default.
- W2022099770 cites W2061270600 @default.
- W2022099770 cites W2061921287 @default.
- W2022099770 cites W2064477710 @default.
- W2022099770 cites W2067470404 @default.
- W2022099770 cites W2067658882 @default.
- W2022099770 cites W2085877659 @default.
- W2022099770 cites W2113320982 @default.
- W2022099770 cites W2114539716 @default.
- W2022099770 cites W2115602884 @default.
- W2022099770 cites W2116714823 @default.
- W2022099770 cites W2126261616 @default.
- W2022099770 cites W2131165436 @default.
- W2022099770 cites W2154690470 @default.
- W2022099770 cites W2160456500 @default.
- W2022099770 cites W2161252670 @default.
- W2022099770 cites W2163663923 @default.
- W2022099770 cites W2164143121 @default.
- W2022099770 cites W2203873715 @default.
- W2022099770 cites W2470104051 @default.
- W2022099770 cites W4251391836 @default.
- W2022099770 cites W2062888920 @default.
- W2022099770 doi "https://doi.org/10.1093/nar/27.15.3153" @default.
- W2022099770 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/148542" @default.
- W2022099770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10454612" @default.
- W2022099770 hasPublicationYear "1999" @default.
- W2022099770 type Work @default.
- W2022099770 sameAs 2022099770 @default.
- W2022099770 citedByCount "51" @default.
- W2022099770 countsByYear W20220997702012 @default.
- W2022099770 countsByYear W20220997702013 @default.
- W2022099770 countsByYear W20220997702014 @default.
- W2022099770 countsByYear W20220997702015 @default.
- W2022099770 countsByYear W20220997702016 @default.
- W2022099770 countsByYear W20220997702017 @default.
- W2022099770 countsByYear W20220997702021 @default.
- W2022099770 countsByYear W20220997702022 @default.
- W2022099770 crossrefType "journal-article" @default.
- W2022099770 hasAuthorship W2022099770A5002170667 @default.
- W2022099770 hasAuthorship W2022099770A5012088953 @default.
- W2022099770 hasAuthorship W2022099770A5030427664 @default.
- W2022099770 hasAuthorship W2022099770A5057306543 @default.
- W2022099770 hasAuthorship W2022099770A5063281832 @default.
- W2022099770 hasAuthorship W2022099770A5086128602 @default.
- W2022099770 hasAuthorship W2022099770A5089917586 @default.
- W2022099770 hasBestOaLocation W20220997702 @default.
- W2022099770 hasConcept C104451858 @default.
- W2022099770 hasConcept C134935766 @default.
- W2022099770 hasConcept C143425029 @default.
- W2022099770 hasConcept C153911025 @default.
- W2022099770 hasConcept C187206112 @default.
- W2022099770 hasConcept C192396546 @default.
- W2022099770 hasConcept C202751555 @default.
- W2022099770 hasConcept C2778378917 @default.
- W2022099770 hasConcept C552990157 @default.
- W2022099770 hasConcept C55493867 @default.
- W2022099770 hasConcept C57600042 @default.
- W2022099770 hasConcept C86803240 @default.
- W2022099770 hasConceptScore W2022099770C104451858 @default.
- W2022099770 hasConceptScore W2022099770C134935766 @default.