FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022100589> ?p ?o ?g. }

• W2022100589 endingPage "567" @default.
• W2022100589 startingPage "557" @default.
• W2022100589 abstract "Ca2+-induced Ca2+ release (CICR) occurs in frog motor nerve terminals after ryanodine receptors (RyRs) are primed for activation by conditioning large Ca2+ entry. We studied which type of RyR exists, whether CICR occurs without conditioning Ca2+ entry and how RyRs are primed. Immunohistochemistry revealed the existence of RyR3 in motor nerve terminals and axons and both RyR1 and RyR3 in muscle fibers. A blocker of RyR, 8-(N,N-diethylamino)octyl 3,4,5-trimethoxybenzoate hydrochloride (TMB-8) slightly decreased rises in intracellular Ca2+ ([Ca2+]i) induced by a short tetanus (50 Hz, 1–2 s), but not after treatment with ryanodine. Repetitive tetani (50 Hz for 15 s every 20 s) produced repetitive rises in [Ca2+]i, whose amplitude overall waxed and waned. TMB-8 blocked the waxing and waning components. Ryanodine suppressed a slow increase in end-plate potentials (EPPs) induced by stimuli (33.3 Hz, 15 s) in a low Ca2+, high Mg2+ solution. KN-62, a blocker of Ca2+/calmoduline-activated protein kinase II (CaMKII), slightly reduced short tetanus-induced rises in [Ca2+]i, but markedly the slow waxing and waning rises produced by repetitive tetani in both normal and low Ca2+, high Mg2+ solutions. Likewise, KN-62, but not KN-04, an inactive analog, suppressed slow increases in EPP amplitude and miniature EPP frequency during long tetanus. Thus, CICR normally occurs weakly via RyR3 activation by single impulse-induced Ca2+ entry in frog motor nerve terminals and greatly after the priming of RyR via CaMKII activation by conditioning Ca2+ entry, thus, facilitating transmitter exocytosis and its plasticity." @default.
• W2022100589 created "2016-06-24" @default.
• W2022100589 creator A5002974385 @default.
• W2022100589 creator A5045249805 @default.
• W2022100589 creator A5048262927 @default.
• W2022100589 creator A5056933585 @default.
• W2022100589 creator A5067986105 @default.
• W2022100589 creator A5071946579 @default.
• W2022100589 creator A5076992332 @default.
• W2022100589 creator A5084991542 @default.
• W2022100589 date "2005-12-01" @default.
• W2022100589 modified "2023-10-10" @default.
• W2022100589 title "Type-3 ryanodine receptor involved in Ca2+-induced Ca2+ release and transmitter exocytosis at frog motor nerve terminals" @default.
• W2022100589 cites W1581695074 @default.
• W2022100589 cites W1599287250 @default.
• W2022100589 cites W1641967096 @default.
• W2022100589 cites W1672275028 @default.
• W2022100589 cites W1718658880 @default.
• W2022100589 cites W1840022026 @default.
• W2022100589 cites W1877112462 @default.
• W2022100589 cites W1888295889 @default.
• W2022100589 cites W1914131776 @default.
• W2022100589 cites W1956859188 @default.
• W2022100589 cites W1965814647 @default.
• W2022100589 cites W1969671440 @default.
• W2022100589 cites W1970578796 @default.
• W2022100589 cites W1972061334 @default.
• W2022100589 cites W1977342063 @default.
• W2022100589 cites W1982801753 @default.
• W2022100589 cites W1983835859 @default.
• W2022100589 cites W1986897813 @default.
• W2022100589 cites W1998232144 @default.
• W2022100589 cites W1999739054 @default.
• W2022100589 cites W2001479401 @default.
• W2022100589 cites W2002403163 @default.
• W2022100589 cites W2004621033 @default.
• W2022100589 cites W2011038097 @default.
• W2022100589 cites W2011880345 @default.
• W2022100589 cites W2012458221 @default.
• W2022100589 cites W2012485096 @default.
• W2022100589 cites W2013907969 @default.
• W2022100589 cites W2017439212 @default.
• W2022100589 cites W2017583361 @default.
• W2022100589 cites W2020396162 @default.
• W2022100589 cites W2044841114 @default.
• W2022100589 cites W2049491065 @default.
• W2022100589 cites W2050561071 @default.
• W2022100589 cites W2057307198 @default.
• W2022100589 cites W2060143162 @default.
• W2022100589 cites W2074655805 @default.
• W2022100589 cites W2074688705 @default.
• W2022100589 cites W2075159086 @default.
• W2022100589 cites W2082262140 @default.
• W2022100589 cites W2085063650 @default.
• W2022100589 cites W2085378902 @default.
• W2022100589 cites W2095152173 @default.
• W2022100589 cites W2095450310 @default.
• W2022100589 cites W2114361822 @default.
• W2022100589 cites W2122054000 @default.
• W2022100589 cites W2126198463 @default.
• W2022100589 cites W2126614230 @default.
• W2022100589 cites W2140207877 @default.
• W2022100589 cites W2150334404 @default.
• W2022100589 cites W2155883881 @default.
• W2022100589 cites W2166478912 @default.
• W2022100589 cites W2169854908 @default.
• W2022100589 cites W2358927500 @default.
• W2022100589 cites W2471454750 @default.
• W2022100589 doi "https://doi.org/10.1016/j.ceca.2005.07.008" @default.
• W2022100589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16157373" @default.
• W2022100589 hasPublicationYear "2005" @default.
• W2022100589 type Work @default.
• W2022100589 sameAs 2022100589 @default.
• W2022100589 citedByCount "21" @default.
• W2022100589 countsByYear W20221005892013 @default.
• W2022100589 countsByYear W20221005892014 @default.
• W2022100589 countsByYear W20221005892015 @default.
• W2022100589 countsByYear W20221005892016 @default.
• W2022100589 countsByYear W20221005892017 @default.
• W2022100589 countsByYear W20221005892018 @default.
• W2022100589 countsByYear W20221005892019 @default.
• W2022100589 countsByYear W20221005892022 @default.
• W2022100589 crossrefType "journal-article" @default.
• W2022100589 hasAuthorship W2022100589A5002974385 @default.
• W2022100589 hasAuthorship W2022100589A5045249805 @default.
• W2022100589 hasAuthorship W2022100589A5048262927 @default.
• W2022100589 hasAuthorship W2022100589A5056933585 @default.
• W2022100589 hasAuthorship W2022100589A5067986105 @default.
• W2022100589 hasAuthorship W2022100589A5071946579 @default.
• W2022100589 hasAuthorship W2022100589A5076992332 @default.
• W2022100589 hasAuthorship W2022100589A5084991542 @default.
• W2022100589 hasConcept C105702510 @default.
• W2022100589 hasConcept C113217602 @default.
• W2022100589 hasConcept C12554922 @default.
• W2022100589 hasConcept C126322002 @default.
• W2022100589 hasConcept C134018914 @default.
• W2022100589 hasConcept C185592680 @default.
• W2022100589 hasConcept C2775912687 @default.

• next