FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022100657> ?p ?o ?g. }

• W2022100657 endingPage "51" @default.
• W2022100657 startingPage "44" @default.
• W2022100657 abstract "Several studies indicate that repeated administration of cocaine can alter GABA(A) receptor function, particularly in the mesolimbic pathway. The purpose of the present study was to assess the effect of cocaine self-administration on GABA(A) receptor activity in the ventral tegmental area (VTA), measured by bicuculline-induced rotational behavior. In order to test whether the hypothesized alteration in GABA(A) receptor function persisted during withdrawal, rats were tested when drug-nai;ve and at two time points after cocaine self-administration. Eighteen rats were implanted with intrajugular catheters and unilateral guide shafts aimed at the VTA. Microinjection of the GABA(A) receptor antagonist bicuculline (10, 25 and 50 ng) produced a dose-dependent turning behavior in a direction ipsilateral to the side of the injection. A subset of six rats was given up to 2 weeks exposure to intravenous cocaine by self-administration and was tested for bicuculline-induced rotations early in withdrawal (24 h) and again at a late withdrawal time point (between 11 and 14 days after the last cocaine session). Cocaine self-administration reduced sensitivity to bicuculline-induced rotations at the early but not at the late withdrawal point, when compared to sensitivity in drug-naive animals. A separate control study that was conducted in seven rats determined that repeated injections of bicuculline in the cocaine self-administration animals was not the cause of the decrease in behavioral response to bicuculline at the early withdrawal time point. These results suggest that exposure to cocaine via self-administration reduces the function of GABA(A) receptors in the ventral midbrain, but this reduction in receptor sensitivity did not persist beyond 10 days of withdrawal from cocaine." @default.
• W2022100657 created "2016-06-24" @default.
• W2022100657 creator A5014974799 @default.
• W2022100657 creator A5018090519 @default.
• W2022100657 creator A5041043150 @default.
• W2022100657 creator A5091438769 @default.
• W2022100657 date "2002-10-01" @default.
• W2022100657 modified "2023-09-23" @default.
• W2022100657 title "Cocaine self-administration alters the locomotor response to microinjection of bicuculline into the ventral tegmental area of rats" @default.
• W2022100657 cites W1557957650 @default.
• W2022100657 cites W1567696719 @default.
• W2022100657 cites W1580993439 @default.
• W2022100657 cites W1966794821 @default.
• W2022100657 cites W1968596825 @default.
• W2022100657 cites W1979399407 @default.
• W2022100657 cites W1983138582 @default.
• W2022100657 cites W1984818619 @default.
• W2022100657 cites W1986592378 @default.
• W2022100657 cites W1987123703 @default.
• W2022100657 cites W1987695404 @default.
• W2022100657 cites W1988301402 @default.
• W2022100657 cites W1999435825 @default.
• W2022100657 cites W2023190048 @default.
• W2022100657 cites W2024246914 @default.
• W2022100657 cites W2025323802 @default.
• W2022100657 cites W2025407295 @default.
• W2022100657 cites W2037060024 @default.
• W2022100657 cites W2041028874 @default.
• W2022100657 cites W2047464854 @default.
• W2022100657 cites W2048896891 @default.
• W2022100657 cites W2054580849 @default.
• W2022100657 cites W2056436878 @default.
• W2022100657 cites W2057573705 @default.
• W2022100657 cites W2065553801 @default.
• W2022100657 cites W2065733295 @default.
• W2022100657 cites W2066113689 @default.
• W2022100657 cites W2075126242 @default.
• W2022100657 cites W2075305798 @default.
• W2022100657 cites W2077150252 @default.
• W2022100657 cites W2080834428 @default.
• W2022100657 cites W2091192459 @default.
• W2022100657 cites W2093165682 @default.
• W2022100657 cites W2112214333 @default.
• W2022100657 cites W2113895006 @default.
• W2022100657 cites W2124028047 @default.
• W2022100657 cites W2143368453 @default.
• W2022100657 cites W2150167216 @default.
• W2022100657 cites W2151683710 @default.
• W2022100657 cites W2165550254 @default.
• W2022100657 cites W2169863475 @default.
• W2022100657 cites W2940489394 @default.
• W2022100657 doi "https://doi.org/10.1016/s0006-8993(02)03192-x" @default.
• W2022100657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12363403" @default.
• W2022100657 hasPublicationYear "2002" @default.
• W2022100657 type Work @default.
• W2022100657 sameAs 2022100657 @default.
• W2022100657 citedByCount "5" @default.
• W2022100657 countsByYear W20221006572012 @default.
• W2022100657 countsByYear W20221006572016 @default.
• W2022100657 countsByYear W20221006572020 @default.
• W2022100657 crossrefType "journal-article" @default.
• W2022100657 hasAuthorship W2022100657A5014974799 @default.
• W2022100657 hasAuthorship W2022100657A5018090519 @default.
• W2022100657 hasAuthorship W2022100657A5041043150 @default.
• W2022100657 hasAuthorship W2022100657A5091438769 @default.
• W2022100657 hasConcept C126322002 @default.
• W2022100657 hasConcept C137183658 @default.
• W2022100657 hasConcept C168258287 @default.
• W2022100657 hasConcept C170493617 @default.
• W2022100657 hasConcept C2776885963 @default.
• W2022100657 hasConcept C2778555786 @default.
• W2022100657 hasConcept C2780763569 @default.
• W2022100657 hasConcept C2780948874 @default.
• W2022100657 hasConcept C42219234 @default.
• W2022100657 hasConcept C513476851 @default.
• W2022100657 hasConcept C62525196 @default.
• W2022100657 hasConcept C71924100 @default.
• W2022100657 hasConcept C79636183 @default.
• W2022100657 hasConcept C98274493 @default.
• W2022100657 hasConceptScore W2022100657C126322002 @default.
• W2022100657 hasConceptScore W2022100657C137183658 @default.
• W2022100657 hasConceptScore W2022100657C168258287 @default.
• W2022100657 hasConceptScore W2022100657C170493617 @default.
• W2022100657 hasConceptScore W2022100657C2776885963 @default.
• W2022100657 hasConceptScore W2022100657C2778555786 @default.
• W2022100657 hasConceptScore W2022100657C2780763569 @default.
• W2022100657 hasConceptScore W2022100657C2780948874 @default.
• W2022100657 hasConceptScore W2022100657C42219234 @default.
• W2022100657 hasConceptScore W2022100657C513476851 @default.
• W2022100657 hasConceptScore W2022100657C62525196 @default.
• W2022100657 hasConceptScore W2022100657C71924100 @default.
• W2022100657 hasConceptScore W2022100657C79636183 @default.
• W2022100657 hasConceptScore W2022100657C98274493 @default.
• W2022100657 hasIssue "1" @default.
• W2022100657 hasLocation W20221006571 @default.
• W2022100657 hasLocation W20221006572 @default.
• W2022100657 hasOpenAccess W2022100657 @default.
• W2022100657 hasPrimaryLocation W20221006571 @default.

• next