FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022101137> ?p ?o ?g. }

• W2022101137 endingPage "R1715" @default.
• W2022101137 startingPage "R1709" @default.
• W2022101137 abstract "Suppressor of cytokine signaling (SOCS) proteins and/or activation of the proinflammatory pathway have been postulated as possible mechanisms that may contribute to skeletal muscle insulin resistance. Thus, the aims of the present investigation were to determine in high-fat-fed skeletal muscle: 1) whether SOCS-3 protein concentration is increased, 2) whether coimmunoprecipitation of SOCS-3 with the insulin receptor-β subunit and/or IRS-1 is increased, and 3) whether select components of the proinflammatory pathway are altered. Thirty-two male Sprague-Dawley rats were assigned to either control (CON, n = 16) or high-fat-fed (HF, n = 16) dietary groups for 12 wk and then subjected to hind limb perfusions in the presence ( n = 8/group) or absence ( n = 8/group) of insulin. Insulin-stimulated skeletal muscle 3-MG transport rates and PI-3 kinase activity were greater ( P < 0.05) in CON. IRS-1 tyrosine phosphorylation was decreased ( P < 0.05), and IRS-1 serine 307 phosphorylation was increased ( P < 0.05) in HF. Insulin receptor-β (IR-β) subunit coimmunoprecipitation with IRS-1 was reduced in HF. SOCS-3 protein concentration and SOCS-3 coimmunoprecipitation with both the IR-β subunit and IRS-1 was increased ( P < 0.05) in HF. IKKα/β serine phosphorylation was increased ( P < 0.05), IκBα protein concentration was decreased ( P < 0.05) and IκBα serine phosphorylation was increased ( P < 0.05) in HF. Increased colocalization of SOCS-3 with both the IR-β subunit and IRS-1 may provide steric hindrance that prevents IRS-1 from interacting with IR-β, while increased IKKβ serine phosphorylation may contribute to increasing IRS-1 serine phosphorylation, both of which independently can have deleterious effects on insulin-stimulated PI-3 kinase activation in high-fat-fed rodent skeletal muscle." @default.
• W2022101137 created "2016-06-24" @default.
• W2022101137 creator A5009092667 @default.
• W2022101137 creator A5024352027 @default.
• W2022101137 creator A5075207287 @default.
• W2022101137 date "2009-06-01" @default.
• W2022101137 modified "2023-10-16" @default.
• W2022101137 title "High-fat feeding increases insulin receptor and IRS-1 coimmunoprecipitation with SOCS-3, IKKα/β phosphorylation and decreases PI-3 kinase activity in muscle" @default.
• W2022101137 cites W1505106993 @default.
• W2022101137 cites W1802136190 @default.
• W2022101137 cites W1874250917 @default.
• W2022101137 cites W1888153172 @default.
• W2022101137 cites W1965102835 @default.
• W2022101137 cites W1979520552 @default.
• W2022101137 cites W1985392564 @default.
• W2022101137 cites W1997361359 @default.
• W2022101137 cites W1998002161 @default.
• W2022101137 cites W2005745228 @default.
• W2022101137 cites W2011210301 @default.
• W2022101137 cites W2012198158 @default.
• W2022101137 cites W2017302657 @default.
• W2022101137 cites W2031637294 @default.
• W2022101137 cites W2038018821 @default.
• W2022101137 cites W2050720508 @default.
• W2022101137 cites W2060492271 @default.
• W2022101137 cites W2066704110 @default.
• W2022101137 cites W2069711307 @default.
• W2022101137 cites W2097838137 @default.
• W2022101137 cites W2098710866 @default.
• W2022101137 cites W2099126367 @default.
• W2022101137 cites W2101994325 @default.
• W2022101137 cites W2107674876 @default.
• W2022101137 cites W2108462699 @default.
• W2022101137 cites W2109648626 @default.
• W2022101137 cites W2122657569 @default.
• W2022101137 cites W2126393987 @default.
• W2022101137 cites W2130850001 @default.
• W2022101137 cites W2131836263 @default.
• W2022101137 cites W2133383405 @default.
• W2022101137 cites W2135294249 @default.
• W2022101137 cites W2137976281 @default.
• W2022101137 cites W2138934442 @default.
• W2022101137 cites W2140310609 @default.
• W2022101137 cites W2140793658 @default.
• W2022101137 cites W2152527784 @default.
• W2022101137 cites W2166099437 @default.
• W2022101137 cites W2172071175 @default.
• W2022101137 cites W2187001057 @default.
• W2022101137 cites W2260945607 @default.
• W2022101137 cites W2331176038 @default.
• W2022101137 cites W2785468108 @default.
• W2022101137 doi "https://doi.org/10.1152/ajpregu.00117.2009" @default.
• W2022101137 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2692786" @default.
• W2022101137 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19386987" @default.
• W2022101137 hasPublicationYear "2009" @default.
• W2022101137 type Work @default.
• W2022101137 sameAs 2022101137 @default.
• W2022101137 citedByCount "48" @default.
• W2022101137 countsByYear W20221011372012 @default.
• W2022101137 countsByYear W20221011372013 @default.
• W2022101137 countsByYear W20221011372014 @default.
• W2022101137 countsByYear W20221011372015 @default.
• W2022101137 countsByYear W20221011372016 @default.
• W2022101137 countsByYear W20221011372017 @default.
• W2022101137 countsByYear W20221011372018 @default.
• W2022101137 countsByYear W20221011372020 @default.
• W2022101137 countsByYear W20221011372021 @default.
• W2022101137 countsByYear W20221011372022 @default.
• W2022101137 crossrefType "journal-article" @default.
• W2022101137 hasAuthorship W2022101137A5009092667 @default.
• W2022101137 hasAuthorship W2022101137A5024352027 @default.
• W2022101137 hasAuthorship W2022101137A5075207287 @default.
• W2022101137 hasBestOaLocation W20221011372 @default.
• W2022101137 hasConcept C100175707 @default.
• W2022101137 hasConcept C104292427 @default.
• W2022101137 hasConcept C104317684 @default.
• W2022101137 hasConcept C112446052 @default.
• W2022101137 hasConcept C11960822 @default.
• W2022101137 hasConcept C126322002 @default.
• W2022101137 hasConcept C134018914 @default.
• W2022101137 hasConcept C164027704 @default.
• W2022101137 hasConcept C184235292 @default.
• W2022101137 hasConcept C185592680 @default.
• W2022101137 hasConcept C2776914184 @default.
• W2022101137 hasConcept C2777391703 @default.
• W2022101137 hasConcept C2777553839 @default.
• W2022101137 hasConcept C2777730290 @default.
• W2022101137 hasConcept C2779306644 @default.
• W2022101137 hasConcept C2779959927 @default.
• W2022101137 hasConcept C55493867 @default.
• W2022101137 hasConcept C62478195 @default.
• W2022101137 hasConcept C71829478 @default.
• W2022101137 hasConcept C71924100 @default.
• W2022101137 hasConcept C75217442 @default.
• W2022101137 hasConcept C86803240 @default.
• W2022101137 hasConcept C95444343 @default.
• W2022101137 hasConceptScore W2022101137C100175707 @default.
• W2022101137 hasConceptScore W2022101137C104292427 @default.

• next