FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022101319> ?p ?o ?g. }

• W2022101319 endingPage "648" @default.
• W2022101319 startingPage "639" @default.
• W2022101319 abstract "Summary OBJECTIVE Growth hormone (GH) replacement therapy in hypopituitary adults is associated with sodium and water retention. The underlying mechanisms are incompletely understood and a possible contribution of altered cortisol metabolism or action has not been evaluated. We have investigated the effect of GH replacement therapy on cortisol metabolism, cortisol binding globulin and In‐vitro glucocorticold sensitivity in a group of adult hypopituitary patients. DESIGN AND PATIENTS We studied 19 adult hypopituitary patients (18 adult onset, Y:F, 6:13), who were receiving conventional hydrocortisone (16 patients), thyroxine (14 patients), triiodothyronine (1 patient), sex steroid (9 patients), human chorionic gonadotrophin (1 patient) or desmopressin (6 patients) replacement during a 6‐month, double blind controlled trial of GH therapy (active: placebo, 8:11) followed by a 6‐month open phase of GH (mean dose: 0·2 IU/kg/week, range 0·051‐0·27) and after a 6‐week washout phase following discontinuation of GH therapy. MEASUREMENTS Twenty‐four‐hour urine free cortisol, cortisol metabolites (CoM), ratio 11‐hydroxy/ll‐oxo CoM (F/E) and ratio 5α/β tetrahydrocortisol were measured at 6 months, 12 months and after the 6 week washout phase. Serum cortisol binding globulin was measured basally, at 6 months, 12 months and after washout. Glucocorticold sensitivity was determined in lymphocyte preparations from 8 patients, during GH therapy and after washout, using an In‐vitro technique dependent on dexamethasone suppression of phytohaemagglutinin‐stimulated thymidine Incorporation into DNA. Plasma renin activity and aidosterone were measured after 6‐12 months GH therapy and after washout. RESULTS After 6 months of GH, In patients on hydrocortisone ( n = 9), there were significant decreases in CoM (mean decrement 21%, P < 0·01), F/E (mean decreased from 1·27to 1·0, P = 0·04; reference range0·33‐1·29) and 5α/5β tetrahydrocortisol (mean decreased from 0·67 to 0·48, P = 0·01) and a subsequent increase after washout. Patients not on hydrocortisone ( n = 2) demonstrated a normal basal F/E falling by 25% on GH therapy but no change in CoM. During 12 months of OH therapy, patients on hydrocortisone ( n = 7) demonstrated a further trend to decrement in CoM ( P = 0·09) which reversed after washout ( P = 0·04). Urine free cortisol tended to fall during OH therapy and Increased significantly following washout after 12 months treatment ( P < 0·02). Serum cortisol binding globulin decreased by 20% ( P < 0·05) during 12 months GH treatment but remained within the reference range. In‐vitro studies demonstrated a trend to reduced giucocorticoid sensitivity on GH therapy; the maximum inhibition of phytohaemaggiutinin by dexamethasone tended to be less on OH therapy ( P = 0·052) and was also lower than in 29 normal volunteers ( P < 0·05). There were no significant changes in plasma renin but there was a small increment in aidosterone in recumbent patients ( P = 0·04) during the open phase of GH therapy in the placebo arm. CONCLUSIONS GH therapy in hypopltuitary adults is associated with an apparent reduction in availability of administered hydrocortisone as measured by urine cortisol metabolites and urine free cortisol. This effect is unlikely to be clinically significant except possibly in ACTH deficient subjects on suboptimal hydrocortisone replacement. The changes in F/E suggest that GH may directly or indirectly modulate the activity of 11β‐hydroxysteroid dehydrogenase. The apparent decrease in giucocorticoid sensitivity during GH therapy, demonstrated in vitro , merits further investigation." @default.
• W2022101319 created "2016-06-24" @default.
• W2022101319 creator A5021268110 @default.
• W2022101319 creator A5023399104 @default.
• W2022101319 creator A5025146794 @default.
• W2022101319 creator A5026827905 @default.
• W2022101319 creator A5035015234 @default.
• W2022101319 creator A5048915333 @default.
• W2022101319 creator A5090324778 @default.
• W2022101319 date "1994-11-01" @default.
• W2022101319 modified "2023-09-29" @default.
• W2022101319 title "The effect of growth hormone replacement on cortisol metabolism and glucocorticoid sensitivity in hypopituitary adults" @default.
• W2022101319 cites W1970021388 @default.
• W2022101319 cites W1982406908 @default.
• W2022101319 cites W1987354827 @default.
• W2022101319 cites W1989315208 @default.
• W2022101319 cites W1999211257 @default.
• W2022101319 cites W2000607618 @default.
• W2022101319 cites W2001118094 @default.
• W2022101319 cites W2002981924 @default.
• W2022101319 cites W2005002040 @default.
• W2022101319 cites W2006192343 @default.
• W2022101319 cites W2007272731 @default.
• W2022101319 cites W2015526883 @default.
• W2022101319 cites W2019976732 @default.
• W2022101319 cites W2020724424 @default.
• W2022101319 cites W2028131204 @default.
• W2022101319 cites W2030973578 @default.
• W2022101319 cites W2036829365 @default.
• W2022101319 cites W2040851277 @default.
• W2022101319 cites W2053073845 @default.
• W2022101319 cites W2053936707 @default.
• W2022101319 cites W2056415845 @default.
• W2022101319 cites W2070763670 @default.
• W2022101319 cites W2082763309 @default.
• W2022101319 cites W2124888129 @default.
• W2022101319 cites W2131223501 @default.
• W2022101319 cites W2143917809 @default.
• W2022101319 cites W2161622680 @default.
• W2022101319 cites W2296419927 @default.
• W2022101319 cites W2331609610 @default.
• W2022101319 cites W2335977314 @default.
• W2022101319 cites W4251625499 @default.
• W2022101319 doi "https://doi.org/10.1111/j.1365-2265.1994.tb01830.x" @default.
• W2022101319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7828353" @default.
• W2022101319 hasPublicationYear "1994" @default.
• W2022101319 type Work @default.
• W2022101319 sameAs 2022101319 @default.
• W2022101319 citedByCount "110" @default.
• W2022101319 countsByYear W20221013192013 @default.
• W2022101319 countsByYear W20221013192014 @default.
• W2022101319 countsByYear W20221013192015 @default.
• W2022101319 countsByYear W20221013192016 @default.
• W2022101319 countsByYear W20221013192017 @default.
• W2022101319 countsByYear W20221013192018 @default.
• W2022101319 countsByYear W20221013192019 @default.
• W2022101319 countsByYear W20221013192020 @default.
• W2022101319 countsByYear W20221013192021 @default.
• W2022101319 countsByYear W20221013192022 @default.
• W2022101319 crossrefType "journal-article" @default.
• W2022101319 hasAuthorship W2022101319A5021268110 @default.
• W2022101319 hasAuthorship W2022101319A5023399104 @default.
• W2022101319 hasAuthorship W2022101319A5025146794 @default.
• W2022101319 hasAuthorship W2022101319A5026827905 @default.
• W2022101319 hasAuthorship W2022101319A5035015234 @default.
• W2022101319 hasAuthorship W2022101319A5048915333 @default.
• W2022101319 hasAuthorship W2022101319A5090324778 @default.
• W2022101319 hasConcept C126322002 @default.
• W2022101319 hasConcept C134018914 @default.
• W2022101319 hasConcept C142724271 @default.
• W2022101319 hasConcept C204787440 @default.
• W2022101319 hasConcept C27081682 @default.
• W2022101319 hasConcept C2778288131 @default.
• W2022101319 hasConcept C2778709874 @default.
• W2022101319 hasConcept C2780841215 @default.
• W2022101319 hasConcept C71315377 @default.
• W2022101319 hasConcept C71924100 @default.
• W2022101319 hasConceptScore W2022101319C126322002 @default.
• W2022101319 hasConceptScore W2022101319C134018914 @default.
• W2022101319 hasConceptScore W2022101319C142724271 @default.
• W2022101319 hasConceptScore W2022101319C204787440 @default.
• W2022101319 hasConceptScore W2022101319C27081682 @default.
• W2022101319 hasConceptScore W2022101319C2778288131 @default.
• W2022101319 hasConceptScore W2022101319C2778709874 @default.
• W2022101319 hasConceptScore W2022101319C2780841215 @default.
• W2022101319 hasConceptScore W2022101319C71315377 @default.
• W2022101319 hasConceptScore W2022101319C71924100 @default.
• W2022101319 hasIssue "5" @default.
• W2022101319 hasLocation W20221013191 @default.
• W2022101319 hasLocation W20221013192 @default.
• W2022101319 hasOpenAccess W2022101319 @default.
• W2022101319 hasPrimaryLocation W20221013191 @default.
• W2022101319 hasRelatedWork W1548669396 @default.
• W2022101319 hasRelatedWork W2019289923 @default.
• W2022101319 hasRelatedWork W2040056410 @default.
• W2022101319 hasRelatedWork W2069420617 @default.
• W2022101319 hasRelatedWork W2084912383 @default.
• W2022101319 hasRelatedWork W2095639129 @default.

• next