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- W2022102582 abstract "The genes for two of the proteins of the plasma lipid transport system, apolipoprotein AI (apoAI) and CIII (apoCIII) have been shown to be closely linked in the human genome. To determine whether additional related genes are located in the vicinity of apoAI and apoCIII genes we cloned and extensively characterized approximately 30 kilobases (kb) of human genomic DNA containing these genes and their flanking sequences. Hybridization studies indicated that a non-repetitive DNA fragment located 12kb 3′ to ApoAI gene contains sequences homologous to a 1.8kb mRNA species in human fetal intestine and adult liver but not in fetal liver, kidney, heart, brain or muscle. A cDNA clone was isolated from an adult human liver library by hybridization homology to DNA sequences located 12kb 3′ to apoAI gene. The nucleotide sequences of this cDNA clone is 74.8% homologous to rat apolipoprotein AIV (apoAIV) cDNA and codes for a protein that is 58.6% identical to the rat apoAIV amino acid sequence. These results indicate that apoAI, apoCIII and apoAIV genes are closely linked in the human genome and suggest that all three of them derived from a common ancestral precursor." @default.
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- W2022102582 date "2008-05-01" @default.
- W2022102582 modified "2023-09-27" @default.
- W2022102582 title "EFFECTS OF A FIXED COMBINATION OF FENOFIBRATE AND PRAVASTATIN ON APOLIPOPROTEINS IN HIGH RISK PATIENTS WITH MIXED HYPERLIPIDEMIA" @default.
- W2022102582 doi "https://doi.org/10.1016/s1567-5688(08)70772-4" @default.
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