Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022104275> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2022104275 endingPage "1316" @default.
- W2022104275 startingPage "1312" @default.
- W2022104275 abstract "The flow properties and viscosity of the vehicle into which drugs are incorporated can be determining factors in the bioavailability of topically applied ophthalmic drugs. It is shown, in rabbits, that when polyvinyl alcohol and methylcellulose are compared on a viscosity basis, there is essentially no difference in the two vehicles with regard to their influence on ocular drug bioavailability. Moreover, the rate of drainage loss for polyvinyl alcohol solutions, as determined by the radioactive technetium technique, compares favorably to methylcellulose solutions of similar viscosity. The relationship between viscosity and contact time or drainage loss of a drug is not a direct one, but an optimum viscosity range exists for polyvinyl alcohol solutions. This optimum range of 12–15 cps in rabbits is identical to that found for methylcellulose and differs considerably from the commonly employed viscosity in commercial preparations. Based on the methylcellulose‐polyvinyl alcohol comparison, it appears that vehicles exhibiting or approximating Newtonian flow properties show comparable effects as ophthalmic vehicles. Finally, a discussion of non‐Newtonian vehicles and their expected behavior in the eye is presented." @default.
- W2022104275 created "2016-06-24" @default.
- W2022104275 creator A5014698357 @default.
- W2022104275 creator A5048678931 @default.
- W2022104275 date "1975-08-01" @default.
- W2022104275 modified "2023-10-11" @default.
- W2022104275 title "Ocular Evaluation of Polyvinyl Alcohol Vehicle in Rabbits" @default.
- W2022104275 cites W1970509576 @default.
- W2022104275 cites W2007210947 @default.
- W2022104275 cites W2015215001 @default.
- W2022104275 cites W2018846234 @default.
- W2022104275 cites W2022696506 @default.
- W2022104275 cites W2031788909 @default.
- W2022104275 cites W2031820673 @default.
- W2022104275 cites W2031905205 @default.
- W2022104275 cites W2045268760 @default.
- W2022104275 cites W2075075634 @default.
- W2022104275 doi "https://doi.org/10.1002/jps.2600640811" @default.
- W2022104275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1151703" @default.
- W2022104275 hasPublicationYear "1975" @default.
- W2022104275 type Work @default.
- W2022104275 sameAs 2022104275 @default.
- W2022104275 citedByCount "192" @default.
- W2022104275 countsByYear W20221042752012 @default.
- W2022104275 countsByYear W20221042752013 @default.
- W2022104275 countsByYear W20221042752014 @default.
- W2022104275 countsByYear W20221042752015 @default.
- W2022104275 countsByYear W20221042752016 @default.
- W2022104275 countsByYear W20221042752017 @default.
- W2022104275 countsByYear W20221042752018 @default.
- W2022104275 countsByYear W20221042752019 @default.
- W2022104275 countsByYear W20221042752020 @default.
- W2022104275 countsByYear W20221042752021 @default.
- W2022104275 countsByYear W20221042752022 @default.
- W2022104275 countsByYear W20221042752023 @default.
- W2022104275 crossrefType "journal-article" @default.
- W2022104275 hasAuthorship W2022104275A5014698357 @default.
- W2022104275 hasAuthorship W2022104275A5048678931 @default.
- W2022104275 hasConcept C121332964 @default.
- W2022104275 hasConcept C127172972 @default.
- W2022104275 hasConcept C136229726 @default.
- W2022104275 hasConcept C159985019 @default.
- W2022104275 hasConcept C178790620 @default.
- W2022104275 hasConcept C181389837 @default.
- W2022104275 hasConcept C185592680 @default.
- W2022104275 hasConcept C192562407 @default.
- W2022104275 hasConcept C2778551929 @default.
- W2022104275 hasConcept C2781066024 @default.
- W2022104275 hasConcept C294558 @default.
- W2022104275 hasConcept C43617362 @default.
- W2022104275 hasConcept C71924100 @default.
- W2022104275 hasConcept C97355855 @default.
- W2022104275 hasConcept C98274493 @default.
- W2022104275 hasConceptScore W2022104275C121332964 @default.
- W2022104275 hasConceptScore W2022104275C127172972 @default.
- W2022104275 hasConceptScore W2022104275C136229726 @default.
- W2022104275 hasConceptScore W2022104275C159985019 @default.
- W2022104275 hasConceptScore W2022104275C178790620 @default.
- W2022104275 hasConceptScore W2022104275C181389837 @default.
- W2022104275 hasConceptScore W2022104275C185592680 @default.
- W2022104275 hasConceptScore W2022104275C192562407 @default.
- W2022104275 hasConceptScore W2022104275C2778551929 @default.
- W2022104275 hasConceptScore W2022104275C2781066024 @default.
- W2022104275 hasConceptScore W2022104275C294558 @default.
- W2022104275 hasConceptScore W2022104275C43617362 @default.
- W2022104275 hasConceptScore W2022104275C71924100 @default.
- W2022104275 hasConceptScore W2022104275C97355855 @default.
- W2022104275 hasConceptScore W2022104275C98274493 @default.
- W2022104275 hasIssue "8" @default.
- W2022104275 hasLocation W20221042751 @default.
- W2022104275 hasLocation W20221042752 @default.
- W2022104275 hasOpenAccess W2022104275 @default.
- W2022104275 hasPrimaryLocation W20221042751 @default.
- W2022104275 hasRelatedWork W1505739641 @default.
- W2022104275 hasRelatedWork W2027491976 @default.
- W2022104275 hasRelatedWork W2044251933 @default.
- W2022104275 hasRelatedWork W2046280088 @default.
- W2022104275 hasRelatedWork W2073177056 @default.
- W2022104275 hasRelatedWork W2099575842 @default.
- W2022104275 hasRelatedWork W2110192055 @default.
- W2022104275 hasRelatedWork W230338489 @default.
- W2022104275 hasRelatedWork W2392947802 @default.
- W2022104275 hasRelatedWork W2567358723 @default.
- W2022104275 hasVolume "64" @default.
- W2022104275 isParatext "false" @default.
- W2022104275 isRetracted "false" @default.
- W2022104275 magId "2022104275" @default.
- W2022104275 workType "article" @default.