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• W2022104807 abstract "<h2>Abstract</h2> To elucidate the mechanism of impaired insulin release in case of non-insulin-dependent diabetes (NIDDM), we investigated insulin release and ⁴⁵Ca⁺⁺ efflux from perifused islets obtained from neonatal streptozotocin diabetic model rats. The model rats were prepared by the intraperitoneal administration of 65 mg/kg streptozotocin (STZ) to neonatal males. Rats treated with STZ did not differ from controls in body weight from 1 week to 16 weeks. The model rats had significant hyperglycemia both in the fasting state and after intraperitoneal administration of 2 g/kg glucose. Although the diameter of the islets from the model rats was not significantly different from that of controls, immunoreactivity to anti-insulin was slightly diminished, and degranulation was slightly observed in B-cells. Insulin content was reduced to 45.6% of the control. Insulin release from the perifused islets of STZ-treated rats responded little to 16.7 mmol/L glucose, but normally to 20 mmol/L arginine in the presence of 5.5 mmol/L glucose. In experiments to test the ⁴⁵Ca⁺⁺ efflux from the perifused islets prelabeled with ⁴⁵Ca⁺⁺, a rise of ⁴⁵Ca⁺⁺ efflux concomitant with the second phase of insulin release from the islets of the model rats was inhibited although a sharp increase of ⁴⁵Ca⁺⁺ efflux concomitant with the first phase of insulin release was maintained. ⁴⁵Ca⁺⁺ uptake for 30 minutes was reduced in the islets from the model rats in the basal and stimulated state of insulin secretion although the incremental ⁴⁵Ca⁺⁺ uptake was similar. It is possible that the abnormal calcium handling in pancreatic B-cells may be one of the causes of defect in insulin release in our model rats. To clarify this possibility, further works will be necessary." @default.
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• W2022104807 date "1987-09-01" @default.
• W2022104807 modified "2023-09-29" @default.
• W2022104807 title "Abnormal calcium handling by perifused pancreatic islets from neonatal streptozotocin diabetic model rats" @default.
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• W2022104807 doi "https://doi.org/10.1016/0026-0495(87)90089-8" @default.
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