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- W2022105407 abstract "Angioimmunoblastic T-cell lymphoma (AILT) represents a subset of T-cell lymphomas but resembles an autoimmune disease in many of its clinical aspects. Despite the phenotype of effector T-cells and high expression of FAS and CTLA-4 receptor molecules, tumor cells fail to undergo apoptosis. We investigated single nucleotide polymorphisms (SNPs) of the FAS and CTLA-4 genes in 94 peripheral T-cell lymphomas. Although allelic frequencies of some FAS SNPs were enriched in AILT cases, none of these occurred at a different frequency compared to healthy individuals. Therefore, SNPs in these genes are not associated with the apoptotic defect and autoimmune phenomena in AILT." @default.
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- W2022105407 date "2008-04-24" @default.
- W2022105407 modified "2023-10-13" @default.
- W2022105407 title "Analysis of single nucleotide polymorphisms in the FAS and CTLA-4 genes of peripheral T-cell lymphomas" @default.
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- W2022105407 doi "https://doi.org/10.1007/s12308-008-0003-y" @default.
- W2022105407 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2712330" @default.
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