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- W2022106380 abstract "The effects of a microfilament-modifier (cytochalasin B), of mitotic spindle-inhibitors (colchicine and vinblastine) and of a microtubule-stabilizer (D2O) on glucagon secretion were studied in vitro, using pieces of pancreas from duct-ligated rats. Cytochalasin B (10 μg/ ml) potentiated arginine-induced glucagon release, but was without effect on unstimulated glucagon release. Colchicine (10−4M) and vinblastine (10−4M) similarly stimulated arginine-induced glucacon release; colchicine did not affect unstimulated glucagon release. Deuterium oxide (100%, v/v) reversibly inhibited arginine-induced glucagon secretion. If it is assumed that the above mentioned drugs specifically interact with microfilaments and microtubules in the A2 cells, our results would suggest that a microtubular-microfilamentous system indeed participates in the process of glucagon secretion. The intimate mechanism by which such a system may apparently play both a restrictive and effector role in glucagon release remains, however, to be elucidated." @default.
- W2022106380 created "2016-06-24" @default.
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- W2022106380 date "1974-06-01" @default.
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- W2022106380 title "Possible role of a microtubular-microfilamentous system in glucagon secretion" @default.
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- W2022106380 doi "https://doi.org/10.1007/bf00423038" @default.
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