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• W2022108154 abstract "99mTechnetium (99mTc) was bound to preformed beclomethasone dipropionate (Bec) dilauroylphosphatidylcholine (DLPC) liposomes (Bec-DLPC) in the presence of the reducing agent, stannous chloride. Labelling efficiency was 96–99% as determined by micropartition and chromatographic analysis. Andersen cascade impactor analysis showed close correlation of the distribution of 99mTc, DLPC, and Bec over the full range of particle sizes sampled. In mouse biodistribution studies, approximately one-half of 99mTc activity delivered to the lungs was retained at 24 h. 99mTc clearance was almost exclusively via the gastrointestinal tract. In contrast, free 99mTc (administered unbound to Bec-DLPC) liposomes was cleared from mouse lungs within a few minutes. Six normal volunteers inhaled 20 breaths of the labelled Bec-DLPC liposome aerosol from each of two nebulizers (Aerotech II, MMAD 1.5μ, GSD 2.4) (Spira, MMAD 3.6μ, GSD 2.5). Immediately following inhalation, the gamma camera analysis showed 17% pulmonary deposition of inhaled 99mTc-Bec-DLPC with the Aerotech II and 14% with the Spira nebulizer. At 3 h after Aerotech II exposure, 93% of deposited activity was retained in the lung and 82% was retained from the Spira nebulizer. These findings suggest that there is a stable association of 99mTc with the Bec-DLPC liposomes and that inhaled liposomes were cleared slowly from the lungs of normal volunteers. The smaller particles produced by the Aerotech II nebulizer are presumably responsible for the somewhat larger deposition and longer persistence of pulmonary activity. These findings encourage further study of this modality of treatment for asthma and related conditions." @default.
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• W2022108154 date "1995-03-01" @default.
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• W2022108154 title "A study of 99mtechnetium-labelled beclomethasone dipropionate dilauroylphosphatidylcholine liposome aerosol in normal volunteers" @default.
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• W2022108154 doi "https://doi.org/10.1016/0378-5173(94)00265-7" @default.
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