FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022110250> ?p ?o ?g. }

• W2022110250 endingPage "4952" @default.
• W2022110250 startingPage "4948" @default.
• W2022110250 abstract "The yeast two-hybrid system was used to isolate a clone from a 17-day-old mouse embryo cDNA library that codes for a novel 812-aa long protein fragment, glucocorticoid receptor-interacting protein 1 (GRIP1), that can interact with the hormone binding domain (HBD) of the glucocorticoid receptor. In the yeast two-hybrid system and in vitro, GRIP1 interacted with the HBDs of the glucocorticoid, estrogen, and androgen receptors in a hormone-regulated manner. When fused to the DNA binding domain of a heterologous protein, the GRIP1 fragment activated a reporter gene containing a suitable enhancer site in yeast cells and in mammalian cells, indicating that GRIP1 contains a transcriptional activation domain. Overexpression of the GRIP1 fragment in mammalian cells interfered with hormone-regulated expression of mouse mammary tumor virus-chloramphenicol acetyltransferase gene and constitutive expression of cytomegalovirus-beta-galactosidase reporter gene, but not constitutive expression from a tRNA gene promoter. This selective squelching activity suggests that GRIM can interact with an essential component of the RNA polymerase II transcription machinery. Finally, while a steroid receptor HBD fused with a GAL4 DNA binding domain did not, by itself, activate transcription of a reporter gene in yeast, coexpression of this fusion protein with GRIP1 strongly activated the reporter gene. Thus, in yeast, GRIP1 can serve as a coactivator, potentiating the transactivation functions in steroid receptor HBDs, possibly by acting as a bridge between HBDs of the receptors and the basal transcription machinery." @default.
• W2022110250 created "2016-06-24" @default.
• W2022110250 creator A5038137463 @default.
• W2022110250 creator A5041411861 @default.
• W2022110250 creator A5068434667 @default.
• W2022110250 creator A5081155699 @default.
• W2022110250 creator A5087055599 @default.
• W2022110250 date "1996-05-14" @default.
• W2022110250 modified "2023-10-13" @default.
• W2022110250 title "GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors." @default.
• W2022110250 cites W1486071030 @default.
• W2022110250 cites W1521828842 @default.
• W2022110250 cites W1559790932 @default.
• W2022110250 cites W1590197184 @default.
• W2022110250 cites W1602722523 @default.
• W2022110250 cites W1889314752 @default.
• W2022110250 cites W192950537 @default.
• W2022110250 cites W1964300769 @default.
• W2022110250 cites W1964337986 @default.
• W2022110250 cites W1971960644 @default.
• W2022110250 cites W1973912514 @default.
• W2022110250 cites W1977186059 @default.
• W2022110250 cites W1981306061 @default.
• W2022110250 cites W1982685209 @default.
• W2022110250 cites W1999131239 @default.
• W2022110250 cites W2003002984 @default.
• W2022110250 cites W2003877378 @default.
• W2022110250 cites W2005914718 @default.
• W2022110250 cites W2006362317 @default.
• W2022110250 cites W2009558707 @default.
• W2022110250 cites W2012430176 @default.
• W2022110250 cites W2017237517 @default.
• W2022110250 cites W2018289835 @default.
• W2022110250 cites W2037065330 @default.
• W2022110250 cites W2038212096 @default.
• W2022110250 cites W2050145162 @default.
• W2022110250 cites W2054743232 @default.
• W2022110250 cites W2055043387 @default.
• W2022110250 cites W2063321023 @default.
• W2022110250 cites W2064194464 @default.
• W2022110250 cites W2068113812 @default.
• W2022110250 cites W2075788654 @default.
• W2022110250 cites W2077679480 @default.
• W2022110250 cites W2077848026 @default.
• W2022110250 cites W2084899156 @default.
• W2022110250 cites W2085124463 @default.
• W2022110250 cites W2090509456 @default.
• W2022110250 cites W2097978662 @default.
• W2022110250 cites W2100837269 @default.
• W2022110250 cites W2128840922 @default.
• W2022110250 cites W2129289858 @default.
• W2022110250 cites W2131882892 @default.
• W2022110250 cites W2150942934 @default.
• W2022110250 cites W2157838103 @default.
• W2022110250 cites W2160402926 @default.
• W2022110250 doi "https://doi.org/10.1073/pnas.93.10.4948" @default.
• W2022110250 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/39385" @default.
• W2022110250 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8643509" @default.
• W2022110250 hasPublicationYear "1996" @default.
• W2022110250 type Work @default.
• W2022110250 sameAs 2022110250 @default.
• W2022110250 citedByCount "667" @default.
• W2022110250 countsByYear W20221102502012 @default.
• W2022110250 countsByYear W20221102502013 @default.
• W2022110250 countsByYear W20221102502014 @default.
• W2022110250 countsByYear W20221102502015 @default.
• W2022110250 countsByYear W20221102502016 @default.
• W2022110250 countsByYear W20221102502017 @default.
• W2022110250 countsByYear W20221102502018 @default.
• W2022110250 countsByYear W20221102502019 @default.
• W2022110250 countsByYear W20221102502020 @default.
• W2022110250 countsByYear W20221102502021 @default.
• W2022110250 countsByYear W20221102502022 @default.
• W2022110250 countsByYear W20221102502023 @default.
• W2022110250 crossrefType "journal-article" @default.
• W2022110250 hasAuthorship W2022110250A5038137463 @default.
• W2022110250 hasAuthorship W2022110250A5041411861 @default.
• W2022110250 hasAuthorship W2022110250A5068434667 @default.
• W2022110250 hasAuthorship W2022110250A5081155699 @default.
• W2022110250 hasAuthorship W2022110250A5087055599 @default.
• W2022110250 hasBestOaLocation W20221102502 @default.
• W2022110250 hasConcept C104317684 @default.
• W2022110250 hasConcept C121608353 @default.
• W2022110250 hasConcept C124170894 @default.
• W2022110250 hasConcept C150194340 @default.
• W2022110250 hasConcept C153911025 @default.
• W2022110250 hasConcept C161733203 @default.
• W2022110250 hasConcept C195598365 @default.
• W2022110250 hasConcept C33987129 @default.
• W2022110250 hasConcept C51445715 @default.
• W2022110250 hasConcept C530470458 @default.
• W2022110250 hasConcept C54355233 @default.
• W2022110250 hasConcept C59493245 @default.
• W2022110250 hasConcept C77445288 @default.
• W2022110250 hasConcept C84606932 @default.
• W2022110250 hasConcept C86339819 @default.
• W2022110250 hasConcept C86803240 @default.
• W2022110250 hasConcept C95444343 @default.

• next